Leptin signaling is required for adaptive changes in food intake, but not energy expenditure, in response to different thermal conditions.
Leptin signaling is required for adaptive changes in food intake, but not energy expenditure, in response to different thermal conditions.
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对于不同的热条件，食物摄入量的自适应变化（而不是能量消耗）需要瘦素信号传导。
DOI：
10.1371/journal.pone.0119391
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Morton GJ
中科院分区：
文献类型：
--
作者：
Kaiyala KJ;Ogimoto K;Nelson JT;Schwartz MW;Morton GJ
自由生活的动物的生存取决于在其热环境快速和剧烈变化的情况下保持核心体温的能力。如果不调整食物摄入量以满足与环境温度变化相关的不断变化的能量需求，可能会对身体能量储存造成严重挑战。为了更全面地了解正常动物中体温调节与能量稳态的耦合，并研究脂肪激素瘦素在这一过程中的作用，我们对瘦素缺乏的ob/ob小鼠及其野生型（WT）同窝对照小鼠在凉爽（14°C）、正常（22°C）或低温中性（30°C）条件下进行了能量稳态和核心温度的全面测量。我们的研究结果扩展了先前的证据，即WT小鼠对环境温度的降低（14°C）或升高（30°C）做出反应，而不会改变体重或身体组成。相比之下，瘦素缺乏的ob/ob小鼠在低于热中性的环境温度下不能防御正常体温，并且当暴露于较冷的环境（14°C）时表现出体脂和瘦体重的显著损失。我们的研究结果进一步证明了野生型小鼠的环境温度和能量消耗之间存在强烈的负相关关系，这种关系在ob/ob小鼠中得到了保留。然而，热传导分析表明缺陷的热保持在ob/ob小鼠，无论温度。虽然环境温度和能量摄入之间的负相关性也存在于WT小鼠中，但这种关系在ob/ob小鼠中被破坏。因此，为了满足不同环境温度的体温调节需求，需要瘦素信号传导来适应能量摄入和热导的变化。更好地了解耦合温度调节能量稳态的机制可能会导致肥胖治疗的新方法的发展。
Survival of free-living animals depends on the ability to maintain core body temperature in the face of rapid and dramatic changes in their thermal environment. If food intake is not adjusted to meet the changing energy demands associated with changes of ambient temperature, a serious challenge to body energy stores can occur. To more fully understand the coupling of thermoregulation to energy homeostasis in normal animals and to investigate the role of the adipose hormone leptin to this process, comprehensive measures of energy homeostasis and core temperature were obtained in leptin-deficient ob/ob mice and their wild-type (WT) littermate controls when housed under cool (14°C), usual (22°C) or ∼ thermoneutral (30°C) conditions. Our findings extend previous evidence that WT mice robustly defend normothermia in response to either a lowering (14°C) or an increase (30°C) of ambient temperature without changes in body weight or body composition. In contrast, leptin-deficient, ob/ob mice fail to defend normothermia at ambient temperatures lower than thermoneutrality and exhibit marked losses of both body fat and lean mass when exposed to cooler environments (14°C). Our findings further demonstrate a strong inverse relationship between ambient temperature and energy expenditure in WT mice, a relationship that is preserved in ob/ob mice. However, thermal conductance analysis indicates defective heat retention in ob/ob mice, irrespective of temperature. While a negative relationship between ambient temperature and energy intake also exists in WT mice, this relationship is disrupted in ob/ob mice. Thus, to meet the thermoregulatory demands of different ambient temperatures, leptin signaling is required for adaptive changes in both energy intake and thermal conductance. A better understanding of the mechanisms coupling thermoregulation to energy homeostasis may lead to the development of new approaches for the treatment of obesity.
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影响因子：
10.9
作者：
Melvin, Richard G.;Andrews, Matthew T.
通讯作者：
Andrews, Matthew T.
影响因子：
4.8
作者：
Golozoubova, V;Hohtola, E;Nedergaard, J
通讯作者：
Nedergaard, J
影响因子：
64.8
作者：
Enerback, S;Jacobsson, A;Kozak, LP
通讯作者：
Kozak, LP
DOI：
10.1152/ajpendo.00546.2010
发表时间：
2011-02-01
影响因子：
5.1
作者：
Morton, Gregory J.;Kaiyala, Karl J.;Wisse, Brent E.
通讯作者：
Wisse, Brent E.
DOI：
10.1007/bf01898005
发表时间：
1970-01-01
期刊：
EXPERIENTIA
影响因子：
--
作者：
CHLOUVERAKIS, C
通讯作者：
CHLOUVERAKIS, C