Familiarity-based recognition in the young, healthy elderly, mild cognitive impaired and Alzheimer's patients
Familiarity-based recognition in the young, healthy elderly, mild cognitive impaired and Alzheimer's patients
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DOI：
10.1016/j.neuropsychologia.2009.03.016
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发表时间：
2009-08-01
期刊：
影响因子：
2.6
通讯作者：
Lacruz, Laura
中科院分区：
文献类型：
--
作者：
Algarabel, Salvador;Escudero, Joaquin;Lacruz, Laura
这项研究调查了五个不同年龄和认知状态的参与者在熟悉度方面可能存在的缺陷。在一项认知测试中，对16名被诊断为多领域认知障碍并有轻微或无记忆障碍的参与者、16名多领域失调症患者和16名阿尔茨海默病患者进行了识别测试，并与老年和年轻健康参与者的同等样本进行了比较。在其中一项测试中，参与者研究了从字母表中有限的一组字母中提取的单词，这些单词后来与另一组新单词混合在一起。将无意识地使用因重复使用字母集而产生的流利性与相同字母集不起作用的情况进行比较。结果表明，遗忘症、轻度认知障碍和阿尔茨海默病患者不能使用字母流畅性来提高识别能力。然而，年轻的控制者和年长的控制者之间没有区别，而记忆成绩与控制者几乎相同的多域样本在强迫选择测试中表现出轻微的熟悉程度缺陷，但在再认测试中没有表现出明显的熟悉性缺陷。这些结果与韦斯特伯格等人报道的结果形成了鲜明对比。[Westberg，C.E.，Pallet，K.E.，Holdstock J.S.，Mayes，A.R.，&Reber，P.J.(2006)。当记忆没有失灵时：轻度认知障碍和阿尔茨海默病患者的基于熟悉度的识别。神经心理学，20,193-205]和Anderson等人。[Anderson，N.D.，Ebert，P.L，Jennings，J.M.，Grady，C.L，Cabeza，R.，&Graham，S.J.(2008年)。健康老龄化和遗忘性轻度认知障碍患者基于回忆和熟悉的记忆。神经心理学，22,177-187]，他得出结论，在这些类型的痴呆症前期和痴呆症患者中没有熟悉性方面的缺陷。(C)2009爱思唯尔有限公司。保留所有权利。
This study investigates the possible existence of deficits in familiarity in five samples of participants spanning a broad range of ages and cognitive states. Five groups of 16 participants with a diagnosis of multi-domain cognitive impairment with a slight or no deficit in memory, 16 multi-domain ammestic, and 16 Alzheimer's disease patients were compared in a recognition test with equivalent samples of old and young healthy participants. in one of the tests, participants studied words extracted from a restricted set of letters of the alphabet that were later mixed with new words from a different set. The unconscious use of the fluency produced by the repeated use of the set of letters was compared with a condition in which the same letter set did not play a role. Results indicated that amnestic mild cognitive impaired and Alzheimer's patients were unable to use letter fluency to improve recognition. However, young and old controls did not differ among themselves, whereas the multi-domain sample, whose memory performance was almost at the same level as that of controls showed slight levels of deficit in familiarity in the forced choice test but not in the recognition test. These results contrast sharply with those reported by Westerberg et al. [Westerberg, C. E., Pallet, K. E., Holdstock J. S., Mayes, A. R., & Reber, p.J. (2006). When memory does not fail: Familiarity-based recognition in mild cognitive impairment and Alzheimer's disease. Neuropsychology, 20, 193-205] and Anderson et al. [Anderson, N. D., Ebert, P. L, Jennings, J. M., Grady, C. L, Cabeza, R., & Graham, S. J. (2008). Recollection- and familiarity-based memory in healthy aging and amnestic mild cognitive impairment. Neuropsychology, 22, 177-187], who concluded that there were no deficits in familiarity in these types of pre-dementia and dementia patients. (C) 2009 Elsevier Ltd. All rights reserved.