Phoenixin-14 enhances memory and mitigates memory impairment induced by Aβ1-42 and scopolamine in mice
Phoenixin-14 enhances memory and mitigates memory impairment induced by Aβ1-42 and scopolamine in mice
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Phoenixin-14 增强小鼠记忆力并减轻 Aβ1-42 和东莨菪碱引起的记忆损伤
DOI：
10.1016/j.brainres.2015.10.030
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发表时间：
2015-12-10
期刊：
影响因子：
2.9
通讯作者：
Wang, R.
中科院分区：
文献类型：
--
作者：
Jiang, J. H.;He, Z.;Wang, R.
菲尼克斯 (PNX) 是一种最近发现的神经肽，显示其参与调节生殖系统、焦虑相关行为和疼痛，但其受体仍不清楚。 PNX-14 是一种内源性活性异构体，据报道可调节促性腺激素释放激素 (GnRH) 受体表达和 GnRH 分泌。由于GnRH系统被认为参与学习和记忆过程的调节，我们推测PNX-14可能是调节学习和记忆的。在这里，我们使用新颖的物体识别 (NOR) 和物体位置识别 (OLR) 任务研究了 PNX-14 在记忆过程中的影响。我们的结果显示，训练后立即脑室内（i.c.v.）注射 PNX-14（25 nmol）不仅促进了记忆形成，而且还延长了两项任务中的记忆保留时间。当 PNX-14 被注入海马体时，也可以看到其增强记忆的作用。此外，PNX-14 的这些记忆改善作用可以被 GnRH 受体拮抗剂 (Cetrorelix) 阻断。 PNX-14 的记忆改善作用与对运动活动的任何影响无关。此外，结果表明 i.c.v.注射 PNX-14 可减轻由淀粉样蛋白-β 1-42 (A beta(1-42)) 肽和东莨菪碱引起的记忆障碍。目前的结果表明，PNX-14 通过激活 GnRH 受体促进记忆形成并延长记忆保留，并减轻 A beta(1-42) 和东莨菪碱的记忆损害作用，表明 PNX-14 可能作为增强记忆和治疗阿尔茨海默病的药物有效。 (C) 2015 Elsevier B.V. 保留所有权利。
Phoenixin (PNX) is a recently discovered neuropeptide shown to be involved in regulating the reproductive system, anxiety-related behaviors and pain though its receptor is still unknown. PNX-14, one of the endogenous active isoforms, is reported to regulate gonadotropin releasing hormone (GnRH) receptor expression and GnRH secretion. Because GnRH system is thought to be involved in the regulation of learning and memory processes, we hypothesized that PNX-14 might be mediate learning and memory. Here, we investigated the effects of PNX-14 in memory processes, using novel object recognition (NOR) and object location recognition (OLR) tasks. Our results revealed that intracerebro-ventricular (i.c.v.) injection of PNX-14 (25 nmol) immediately after training not only facilitated memory formation, but also prolonged memory retention in both tasks. The memory-enhancing effects of PNX-14 were also seen when it was infused into the hippocampus. Moreover, these memory-improving effects of PNX-14 could be blocked by a GnRH receptor antagonist (Cetrorelix). The memory-improving effects of PNX-14 were not related to any effects on locomotor activity. Additionally, the results suggested that i.c.v. injection of PNX-14 mitigate the memory impairment induced by the amyloid-beta 1-42 (A beta(1-42)) peptide and scopolamine. The present results indicate that PNX-14 facilitates memory formation and prolongs memory retention through activation of the GnRH receptor, and mitigates the memory-impairing effects of A beta(1-42) and scopolamine, suggesting that PNX-14 may be effective as a drug for enhancing memory and treating Alzheimer's disease. (C) 2015 Elsevier B.V. All rights reserved.