NK cells: a double-edged sword in chronic hepatitis B virus infection.
NK cells: a double-edged sword in chronic hepatitis B virus infection.
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DOI：
10.3389/fimmu.2013.00057
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发表时间：
2013
影响因子：
7.3
通讯作者：
Peppa D
中科院分区：
文献类型：
--
作者：
Maini MK;Peppa D
NK细胞在人肝脏中天然富集，并且这种肝内优势强调了它们在控制嗜肝病毒如肝炎B病毒（HBV）感染中的潜在重要性。先天性成分在慢性HBV感染中的作用一直是一个相对研究不足的领域。然而，最近的数据表明，NK细胞能够发挥抗病毒和免疫调节功能，同时还通过死亡受体途径促进肝损伤的发病机制。我们将概述NK细胞在慢性B型肝炎中抗病毒与致病作用的背景下的复杂生物学，作为进一步研究的临床相关途径。
There is natural enrichment of NK cells in the human liver and this intrahepatic predominance underscores their potential importance in the control of infections with hepatotropic viruses such as hepatitis B virus (HBV). The contribution of innate components during chronic HBV infection has been a relatively under-investigated area. However, recent data have highlighted that NK cells are capable of exerting antiviral and immunoregulatory functions whilst also contributing to the pathogenesis of liver injury via death receptor pathways. We will present an overview of current knowledge regarding the complex biology of NK cells in the context of their antiviral versus pathogenic role in chronic hepatitis B as a clinically relevant avenue for further investigation.