Epidemiologic evidence of cardiovascular effects of particulate air pollution
Epidemiologic evidence of cardiovascular effects of particulate air pollution
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DOI：
10.2307/3454657
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发表时间：
2001-08-01
影响因子：
10.4
通讯作者：
Dockery, DW
中科院分区：
文献类型：
--
作者：
Dockery, DW
在过去的十年里，研究人员发现了大量的流行病学证据，表明急性暴露于颗粒空气污染中与每日心血管死亡率和发病率增加有关。不仅与死亡证明上报告的心血管死亡有关，而且还与心肌梗死和心室颤动有关。接触颗粒空气污染与心脏自主功能指标相关，包括心率增加、心率变异性降低和心律失常增加。心源性猝死风险增加的几个标志也与此类接触有关。这些流行病学研究为颗粒空气污染对健康影响的可能途径提供了早期指导，这只能在毒理学和生理学研究中得到充分解决。
In the past decade researchers have developed a body of epidemiologic evidence showing increased daily cardiovascular mortality and morbidity associated with acute exposures to particulate air pollution. Associations have been found not only with cardiovascular deaths reported on death certificates but also with myocardial infarctions and ventricular fibrillation. Particulate air pollution exposure has been associated with indicators of autonomic function of the heart including increased heart rate, decreased heart rate variability, and increased cardiac arrhythmias. Several markers of increased risk for sudden cardiac death have also been associated with such exposures. These epidemiologic studies provide early guidance to possible pathways of particulate air pollution health effects, which can only be addressed fully in toxicologic and physiologic studies.