Pediatric hepatobiliary disease
Pediatric hepatobiliary disease
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小儿肝胆疾病
DOI：
10.1097/00001574-199509000-00013
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
J. Heubi
中科院分区：
文献类型：
--
作者：
J. Heubi
三个领域突出了儿童肝胆疾病的进展。首先，提高对囊性纤维化患者肝胆疾病发展的危险因素的理解，可以更好地设计研究来评估潜在治疗干预措施的益处。其次，尽管自引入原位肝移植以来胆道闭锁儿童的生存率有所提高，但其原因和决定胆道疾病进展速度的因素仍然难以捉摸。最后，对于有针对性的儿童人群，如镰状细胞病患者，腹腔镜胆囊切除术的使用增加，将从降低发病率和成本中获得显著收益。
Three areas highlight the advances made in pediatric hepatobiliary disease. First, improved understanding of risk factors for the development of hepatobiliary disease in cystic fibrosis may allow better study designs to assess the benefit of potential therapeutic interventions. Second, despite improved survival of children with biliary atresia since the introduction of orthotopic liver transplantation, its cause and factors determining the rate of progression of the cholangiopathy remain elusive. Finally, the increased use of laparoscopic cholecystectomy for targeted pediatric populations, such as those with sickle cell disease, will lead to significant benefits from reduced morbidity and cost.