Enhancement of human motor cortex inhibition by the dopamine receptor agonist pergolide: evidence from transcranial magnetic stimulation
Enhancement of human motor cortex inhibition by the dopamine receptor agonist pergolide: evidence from transcranial magnetic stimulation
复制标题
多巴胺受体激动剂培高利特增强人类运动皮层抑制：来自经颅磁刺激的证据
DOI：
10.1016/0304-3940(96)12575-1
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发表时间：
1996
影响因子：
2.5
通讯作者：
W. Paulus
中科院分区：
文献类型：
--
作者：
U. Ziemann;D. Bruns;W. Paulus
使用局灶性经颅磁刺激来评估单次口服剂量（0.125 mg）的多巴胺受体激动剂培高利特对5名健康受试者运动皮层兴奋性的影响。小指展肌的静息和主动运动阈值不受影响。皮质沉默期的平均持续时间显着延长了22毫秒。皮质-皮质抑制研究的配对条件试验刺激（刺激间隔1-5毫秒）显着增强，而皮质-皮质促进在较长的时间间隔（6- 1-5毫秒），只显示出一个微不足道的趋势，对较少的便利。所有作用均在给药后3 h达到峰值，24 h后可逆。外周运动兴奋性测试的持续时间的外周沉默期和最大M波的大小保持不变。目前的数据支持培高利特能够增强运动皮层抑制的观点，已知运动皮层抑制在特发性帕金森病中是缺乏的。
Focal transcranial magnetic stimulation was used to evaluate the effect a single oral dose (0.125 mg) of the dopamine agonist pergolide on the excitability of the motor cortex in five healthy subjects. Resting and active motor thresholds of the abductor digiti minimi muscle were unaffected. The mean duration of the cortical silent period was significantly lengthened by up to 22 ms. The cortico-cortical inhibition as studied by a paired conditioning-test stimulation (interstimulus intervals of 1–5 ms) was enhanced significantly while the cortico-cortical facilitation at longer intervals (6–15 ms) showed only an insignificant trend towards less facilitation. All effects peaked at 3 h after drug intake and were reversible after 24 h. Peripheral motor excitability as tested by the duration of the peripheral silent period and the size of the maximum M wave remained unchanged. The present data support the view that pergolide is capable of enhancing motor cortex inhibition which is known to be deficient in idiopathic Parkinson's disease.