HIV incidence among injection drug users in New York City, 1992-1997: Evidence for a declining epidemic
HIV incidence among injection drug users in New York City, 1992-1997: Evidence for a declining epidemic
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DOI：
10.2105/ajph.90.3.352
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发表时间：
2000-03-01
影响因子：
12.7
通讯作者：
Friedman, SR
中科院分区：
文献类型：
--
作者：
Des Jarlais, DC;Marmor, M;Friedman, SR
目标。我们评估了最近(1992-1997年)在纽约市注射吸毒者中HIV大规模流行中的HIV发病率。数据来自10项独立的研究(N=4979)，包括6项队列研究，2项“重复服务使用者”研究，以及2项关于药物治疗项目中自愿艾滋病毒检测和咨询服务的分析。在这10项研究中，在6344人年的高危人群中发现52例血清转换。10项研究中观察到的发病率都在一个狭窄的范围内，从每100人危险年0到每100人危险年2.95。在10项研究中，有9项观察到的发病率低于每100个高危人群年2例。高危人群加权平均发病率为0.7/100人年。对于注射吸毒者的高血清阳性人群来说，纽约市最近的发病率相当低。纽约市注射吸毒者中艾滋病毒的大规模流行似乎进入了一个“下降阶段”，其特点是发病率低，流行率下降。这些数据表明，非常大的高血清阳性率的艾滋病毒流行可能会被“逆转”。
Objectives. We assessed recent (1992-1997) HIV incidence in the large HIV epidemic among injection drug users in New York City.Methods. Data were compiled from 10 separate studies (N=4979), including 6 cohort studies, 2 "repeat service user" studies, and 2 analyses of voluntary HIV testing and counseling services within drug treatment programs.Results. In the 10 studies, 52 seroconversions were found in 6344 person-years at risk. The observed incidence rates among the 10 studies were all within a narrow range, from 0 per 100 person-years at risk to 2.95 per 100 person-years at risk. In 9 of the 10 studies, the observed incidence rate was less than 2 per 100 person-years at risk. The weighted average incidence rate was 0.7 per 100 person-years at risk.Conclusions. The recent incidence rate in New York City is quite low for a high-seroprevalence population of injection drug users. The very large HIV epidemic among injection drug users in New York City appears to have entered a "declining phase," characterized by low incidence and declining prevalence. The data suggest that very large high-seroprevalence HIV epidemics may be "reversed.".