CIS-DIAMMINEDICHLOROPLATINUM (DDP) AS INITIAL TREATMENT OF INVASIVE BLADDER-CANCER
CIS-DIAMMINEDICHLOROPLATINUM (DDP) AS INITIAL TREATMENT OF INVASIVE BLADDER-CANCER
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DOI：
10.1111/j.1464-410x.1984.tb05390.x
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发表时间：
1984-01-01
期刊：
影响因子：
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通讯作者：
FIELDING, JWL
中科院分区：
文献类型：
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作者：
FAGG, SL;DAWSONEDWARDS, P;FIELDING, JWL
顺式二胺二氯铂（DDP）被用作17例活检证实的膀胱移行细胞癌患者的初步治疗。患者此前均未接受过放疗或化疗。肿瘤临床分期为T2（2例）、T3（13例）、T4（2例）。治疗前通过膀胱镜、活检、麻醉下检查（EUA）、计算机轴向断层扫描（CT）和超声对肿瘤进行评估。DDP以100mg /m2的剂量静脉滴注，同时用甘露醇和生理盐水水化。每例患者每3周接受3次治疗。第3次治疗12 d后，通过膀胱镜、活检、EUA、CT扫描和超声评估疗效。在17名患者中，11名患者有部分反应。与无应答者相比，应答者的生存率显著提高。7例患者在治疗后出现低肌酐清除率，5例患者有听力图显示耳毒性，2例患者在治疗期间出现白细胞减少。本研究证实了DDP在膀胱癌中的活性，并表明它在17例患者中的11例原发肿瘤中产生了活性反应。
Cis-diamminedichloroplatinum (DDP) was used as the initial treatment in a pilot study of 17 patients with biopsy-proven transitional cell carcinoma of the bladder. No patient had received any previous radiotherapy or chemotherapy. The clinical stages of the tumors were T2 (2 patients), T3 (13) and T4 (2). Before treatment the tumors were assessed by cystoscopy, biopsy, examination under anesthesia (EUA), computed axial tomography (CT scan) and ultrasound. DDP was given at a dose of 100 mg/m2 i.v. with hydration using mannitol and saline. Each patient received 3 treatments at 3-weekly intervals. Twelve days after the 3rd treatment, response was assessed by cystoscopy, biopsy, EUA, CT scan and ultrasound. Of the 17 patients, 11 had a partial response. Survival was significantly increased in responders compared with nonresponders. Seven patients had a low creatinine clearance following treatment, 5 had audiograms showing evidence of ototoxicity and 2 developed leukopenia during treatment. This study confirmed the activity of DDP in bladder cancer and showed that it was active in producing a response in the primary tumor in 11 of 17 patients.