Selective repression of gene expression in neuropathic pain by the neuron-restrictive silencing factor/repressor element-1 silencing transcription (NRSF/REST).
Selective repression of gene expression in neuropathic pain by the neuron-restrictive silencing factor/repressor element-1 silencing transcription (NRSF/REST).
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DOI：
10.1016/j.neulet.2015.12.003
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发表时间：
2016-06-20
影响因子：
2.5
通讯作者：
Cave JW
中科院分区：
文献类型：
--
作者：
Willis DE;Wang M;Brown E;Fones L;Cave JW
神经性疼痛通常在神经损伤后发展，这是由于在受损神经中以及沿着外周和中枢神经系统的伤害感受通路发生的适应不良变化。多种细胞和分子机制可能解释了这些变化;然而，这些机制的确切性质在很大程度上仍然未知。越来越多的研究表明，基因表达的改变是从急性疼痛状态进展到慢性疼痛状态的重要步骤，并且已经提出了表观遗传调控来驱动基因表达的这种变化。在这篇综述中，我们讨论了最近的证据表明，DNA结合蛋白神经元限制性沉默因子/阻遏元件-1沉默转录因子NRSF/REST）是一个重要的组成部分，在神经性疼痛的发展和维持，通过其作为一个转录调节子的选择子集的基因，它通常在发展过程中抑制的作用。
Neuropathic pain often develops following nerve injury as a result of maladaptive changes that occur in the injured nerve and along the nociceptive pathways of the peripheral and central nervous systems. Multiple cellular and molecular mechanisms likely account for these changes; however, the exact nature of these mechanisms remain largely unknown. A growing number of studies suggest that alteration in gene expression is an important step in the progression from acute to chronic pain states and epigenetic regulation has been proposed to drive this change in gene expression. In this review, we discuss recent evidence that the DNA-binding protein Neuron-Restrictive Silencing Factor/Repressor Element-1 Silencing Transcription factor NRSF/REST) is an important component in the development and maintenance of neuropathic pain through its role as a transcriptional regulator for a select subset of genes that it normally represses during development.