Distribution of Brain Sodium Accumulation Correlates with Disability in Multiple Sclerosis: A Cross-sectional 23Na MR Imaging Study
Distribution of Brain Sodium Accumulation Correlates with Disability in Multiple Sclerosis: A Cross-sectional 23Na MR Imaging Study
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DOI：
10.1148/radiol.12112680
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发表时间：
2012-09-01
期刊：
影响因子：
19.7
通讯作者：
Ranjeva, Jean-Philippe
中科院分区：
文献类型：
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作者：
Zaaraoui, Wafaa;Konstandin, Simon;Ranjeva, Jean-Philippe
目的：为了量化脑钠积累和表征的第一次钠异常的空间位置在不同阶段的复发缓解型（RR）多发性硬化症（MS）通过使用钠23（Na-23）磁共振（MR）imaging.Materials and Methods：这项研究是由当地伦理委员会批准，并获得所有参与者的书面知情同意书。采用3.0-T装置对两组RR MS患者进行了三维Na-23 MR成像，其中14例为早期RR MS（病程5年），12例为晚期RR MS（病程5年
Purpose: To quantify brain sodium accumulations and characterize for the first time the spatial location of sodium abnormalities at different stages of relapsing-remitting (RR) multiple sclerosis (MS) by using sodium 23 (Na-23) magnetic resonance (MR) imaging.Materials and Methods: This study was approved by the local committee on ethics, and written informed consent was obtained from all participants. Three-dimensional Na-23 MR imaging data were obtained with a 3.0-T unit in two groups of patients with RR MS-14 with early RR MS (disease duration,5 years) and 12 with advanced RR MS (disease duration