Essramycin: A first triazolopyrimidine antibiotic isolated from nature
Essramycin: A first triazolopyrimidine antibiotic isolated from nature
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DOI：
10.1038/ja.2008.124
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发表时间：
2008-03-01
影响因子：
3.3
通讯作者：
Laatsch, Hartmut
中科院分区：
文献类型：
--
作者：
El-Gendy, Mervat M. A.;Shaaban, Mohamed;Laatsch, Hartmut
在我们筛选新的生物活性化合物的过程中，从海洋链霉菌的培养液中获得了一种新的三唑并嘧啶类抗生素--艾司拉霉素（1），分离Merv 8102。通过密集的NMR研究和质谱确定结构1。该化合物具有抗菌活性，对革兰氏阳性和革兰氏阴性细菌的MIC为2至8 μ g/ml，而它没有显示出抗真菌活性。介绍了1的发酵、分离、结构鉴定和生物活性。
In the course of our screening program for new bio-active compounds, a novel triazolopyrimidine antibiotic, essramycin (1), was obtained from the culture broth of the marine Streptomyces sp., isolate Merv8102. Structure 1 was established by intensive NMR studies and by mass spectra. The compound is antibacterially active with MIC of 2 to 8 mu g/ml against Gram-positive and Gram-negative bacteria, while it showed no antifungal activity. The fermentation and isolation, as well as the structure elucidation and biological activity of 1 are described.