Effect of liver glycogen content on glucose production in running rats.
Effect of liver glycogen content on glucose production in running rats.
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肝糖原含量对跑步大鼠葡萄糖产生的影响。
DOI：
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发表时间：
1989
影响因子：
3.3
通讯作者：
Henrik Galbo
中科院分区：
文献类型：
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作者：
John Vissing;J. Wallace;Henrik Galbo
在长期插管大鼠中研究了运动过程中超正常与正常肝糖原水平对肝葡萄糖生成（Ra）的影响。通过24小时禁食-24小时再喂养方案获得超正常肝糖原水平。在21 m/min跑台运动35 min时，禁食大鼠的Ra和血糖升高幅度大于对照组（P <0.05），肝糖原分解也大于对照组（P <0.05），但对照组大鼠的Ra升高幅度大于禁食组，而胰岛素和血糖浓度低于禁食组（P <0.05）。此外，与禁食大鼠相比，对照组的胰高血糖素和两种儿茶酚胺的血浆浓度往往较高，肌肉糖原分解较低。两组的脂质代谢相似。结果表明，运动时肝糖原分解与肝糖原含量直接相关。与对照组大鼠相比，禁食大鼠在较高血糖浓度下的较小内分泌糖原分解信号表明运动期间葡萄糖动员的代谢反馈控制。然而，与对照组大鼠相比，禁食大鼠中运动诱导的Ra、血糖和肝糖原分解的增加更高，表明代谢反馈机制无法准确地将Ra与工作肌肉的代谢需求相匹配。
The influence of supranormal compared with normal hepatic glycogen levels on hepatic glucose production (Ra) during exercise was investigated in chronically catheterized rats. Supranormal hepatic glycogen levels were obtained by a 24-h fast-24-h refeeding regimen. During treadmill running for 35 min at a speed of 21 m/min, Ra and plasma glucose increased more (P less than 0.05) and liver glucogen breakdown was larger in fasted-refed compared with control rats, although the stimuli for Ra were higher in control rats, the plasma concentrations of insulin and glucose being lower (P less than 0.05) in control compared with fasted-refed rats. Also, plasma concentrations of glucagon and both catecholamines tended to be higher and muscle glycogenolysis lower in control compared with fasted-refed rats. Lipid metabolism was similar in the two groups. The results indicate that hepatic glycogenolysis during exercise is directly related to hepatic glycogen content. The smaller endocrine glycogenolytic signal in face of higher plasma glucose concentrations in fasted-refed compared with control rats is indicative of metabolic feedback control of glucose mobilization during exercise. However, the higher exercise-induced increase in Ra, plasma glucose, and liver glycogen breakdown in fasted-refed compared with control rats indicates that metabolic feedback mechanisms are not able to accurately match Ra to the metabolic needs of working muscles.