Children's hair cortisol as a biomarker of stress at school entry
Children's hair cortisol as a biomarker of stress at school entry
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DOI：
10.3109/10253890.2013.817553
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发表时间：
2013-11-01
影响因子：
2.3
通讯作者：
van IJzendoorn, Marinus H.
中科院分区：
文献类型：
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作者：
Groeneveld, Marleen G.;Vermeer, Harriet J.;van IJzendoorn, Marinus H.
头皮毛发中皮质醇的定量似乎是长期皮质醇水平的一种有希望的测量方法，因此也是压力的生物标志物。我们研究了头发皮质醇浓度（HCC）的儿童时，第一次进入小学。参与者为42名儿童（45%为男孩），平均年龄为4.2岁（SD = 0.42个月）。入学后2个月采集头发样本（>= 5 cm）。使用两个2厘米长的片段进行头发分析，反映上学的前2个月（头皮附近的片段）和入学前2个月。HCC在入学后高于入学前，特别是对于恐惧的儿童。HCC的改变不受入学前集体日托经验的影响。因此，HCC表明，开始小学伴随着年轻（特别是恐惧）儿童的压力激素水平增加。
Quantification of cortisol in scalp hair seems a promising measurement for long-term cortisol levels, and thereby a biomarker for stress. We examined hair cortisol concentrations (HCC) in children when first entering elementary school. Participants were 42 children (45% boys) with a mean age of 4.2 years (SD = 0.42 months). Hair samples (>= 5 cm) were collected 2 months after school entry. Hair analysis was conducted using two 2-cm long segments, reflecting the first 2 months of school attendance (the scalp-near segment) and 2 months prior to school entry. HCC were higher after school entry than before, especially for fearful children. Alterations in HCC were not moderated by experience in group daycare before school entry. Thus, HCC suggest that starting elementary school is accompanied by increased stress hormone levels in young (in particular fearful) children.