Trajectories of relationship stress and inflammatory processes in adolescence.
Trajectories of relationship stress and inflammatory processes in adolescence.
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DOI：
10.1017/s0954579415000334
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发表时间：
2016-02
影响因子：
3.3
通讯作者：
Adam, Emma K.
中科院分区：
文献类型：
--
作者：
Ehrlich, Katherine B.;Miller, Gregory E.;Rohleder, Nicolas;Adam, Emma K.
研究人员已经确定了人际压力和炎症之间的横向联系。然而，人们对这些动态如何随着时间的推移而展开、可能存在哪些潜在的免疫途径，或者种族等调节因素是否可以改变人际压力和炎症过程之间的联系强度，知之甚少。我们研究了以慢性压力为特征的关系轨迹的青春期女孩是否会表现出以全身炎症为标志的促炎表型、对细菌挑战的细胞因子反应增强以及对皮质醇抗炎特性的抵抗。显着的压力×种族相互作用表明，家庭压力轨迹预测糖皮质激素敏感性，而同伴压力轨迹预测白人女孩细胞因子的产生，但亚洲女孩则不然。然而，关系压力轨迹与全身炎症无关。这些发现表明，在亲密关系中面临长期和较高压力的特定青春期女孩亚群可能面临免疫系统遭到破坏的风险。
Researchers have identified cross-sectional links between interpersonal stress and inflammation. Little is known, however, about how these dynamics unfold over time, what underlying immune pathways might exist, or whether moderators, such as race, could alter the strength of the connection between interpersonal stress and inflammatory processes. We examined whether adolescent girls whose relationship trajectories were characterized by chronic stress would exhibit a pro-inflammatory phenotype marked by systemic inflammation, heightened cytokine responses to bacterial challenges, and resistance to the anti-inflammatory properties of cortisol. Significant Stress × Race interactions revealed that family stress trajectories predicted glucocorticoid sensitivity and peer stress trajectories predicted cytokine production for White but not Asian girls. Relationship stress trajectories were not associated with systemic inflammation, however. These findings suggest that particular subgroups of adolescent girls, who face chronic and elevated stress in their close relationships, may be at risk for disruptions to the immune system.