Effects of depression, metabolic syndrome, and cardiorespiratory fitness on mortality: results from the Cooper Center Longitudinal Study.
Effects of depression, metabolic syndrome, and cardiorespiratory fitness on mortality: results from the Cooper Center Longitudinal Study.
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DOI：
10.1017/s0033291717000897
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发表时间：
2017-10
影响因子：
6.9
通讯作者：
DeFina LF
中科院分区：
文献类型：
--
作者：
Rethorst CD;Leonard D;Barlow CE;Willis BL;Trivedi MH;DeFina LF
抑郁症和代谢综合征（MetS）通常是与过早死亡独立相关的合并症。相反，心肺健康（CRF）与降低死亡风险相关。这些因素可能相互作用影响死亡率；然而，它们的影响尚未同时得到评估。该分析评估了合并抑郁症/MetS的死亡率风险以及CRF对抑郁症/MetS患者死亡率的影响。库珀中心纵向研究中47702名成年人的前瞻性研究。死亡率状况从国家死亡指数获得。抑郁史通过患者对标准化病史问卷的回答（是或否）来确定。MetS采用美国心脏协会/国家心脏、肺和血液研究所的标准进行分类。CRF是根据跑步机分级运动测试的最终速度/等级来估计的。13.9%的人有抑郁史，21.4%的人符合MetS标准，3.0%的人同时符合MetS和抑郁史的标准。抑郁史（HR = 1.24, p = 0.003）和MetS （HR = 1.28, p < 0.001）与死亡风险增加独立相关，同时有抑郁史和MetS的个体死亡风险最高（HR = 1.59, p < 0.001）。在所有个体中，较高的CRF与显著降低的死亡风险相关（p < 0.001），包括那些患有MetS和/或有抑郁症史的个体。CRF水平较高的患者在抑郁症/MetS背景下的死亡风险降低。改善CRF的干预措施可能对抑郁症/MetS患者的健康产生重大影响。
Depression and metabolic syndrome (MetS) are frequently comorbid disorders that are independently associated with premature mortality. Conversely, cardiorespiratory fitness (CRF) is associated with reduced mortality risk. These factors may interact to impact mortality; however, their effects have not been assessed concurrently. This analysis assessed the mortality risk of comorbid depression/MetS and the effect of CRF on mortality in those with depression/MetS. Prospective study of 47 702 adults in the Cooper Center Longitudinal Study. Mortality status was attained from the National Death Index. History of depression was determined by patient response (yes or no) to a standardized medical history questionnaire. MetS was categorized using the American Heart Association/National Heart, Lung, and Blood Institute criteria. CRF was estimated from the final speed/grade of a treadmill graded exercise test. 13.9% reported a history of depression, 21.4% met criteria for MetS, and 3.0% met criteria for both MetS and history of depression. History of depression (HR = 1.24, p = 0.003) and MetS (HR = 1.28, p < 0.001) were independently associated with an increased mortality risk, with the greatest mortality risk among individuals with both a history of depression and MetS (HR = 1.59, p < 0.001). Higher CRF was associated with a significantly lower risk of mortality (p < 0.001) in all individuals, including those with MetS and/or a history of depression. Those with higher levels CRF had reduced mortality risk in the context of depression/MetS. Interventions that improve CRF could have substantial impact on the health of persons with depression/MetS.