ANP32A regulates histone H3 acetylation and promotes leukemogenesis
ANP32A regulates histone H3 acetylation and promotes leukemogenesis
复制标题
ANP32A 调节组蛋白 H3 乙酰化并促进白血病发生。
DOI：
10.1038/s41375-018-0010-7
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发表时间：
2018-07-01
期刊：
影响因子：
11.4
通讯作者：
Huang, Zan
中科院分区：
文献类型：
--
作者：
Yang, Xuejing;Lu, Bin;Huang, Zan
Deregulation of key regulators of histone modification is important in the initiation and progression of human leukemia. Acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) participates in histone acetylation and its role in acute myeloid leukemia remains unclear. Here we observed significant upregulation of ANP32A in primary AML cells, which was essential for AML cell proliferation, survival, and colony formation. Integrative analysis of the genome-wide histone H3 acetylation and gene expression demonstrated that ANP32A deficiency reduced histone H3 acetylation, in accordance with changes in gene expression. Notably, significant histone H3 acetylation enrichment was associated with mRNA changes in lipid-related genes, including APOC1, PCSK9, P2RX1, and LPPR3. Indeed, over-expression of APOC1 partially compensated the proliferation-defect phenotype in ANP32A deficient AML cells while APOC1 knockdown alone mimicked the effect of ANP32A deficiency. Collectively, our data indicate that ANP32A is a novel regulator of histone H3 acetylation and promotes leukemogenesis.
