Case-Control Study of Diarrheal Disease Etiology in a Remote Rural Area in Western Thailand
Case-Control Study of Diarrheal Disease Etiology in a Remote Rural Area in Western Thailand
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DOI：
10.4269/ajtmh.2010.10-0367
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发表时间：
2010-11-01
影响因子：
3.3
通讯作者：
Mason, Carl J.
中科院分区：
文献类型：
--
作者：
Bodhidatta, Ladaporn;McDaniel, Philip;Mason, Carl J.
目的是评估肠道病原体与泰国偏远农村地区腹泻病的关系，收集了236例3个月至5岁急性腹泻患儿（例）和236例无症状对照者的粪便标本，并采用标准微生物学方法和酶免疫法检测病毒性病原体贾第虫和隐孢子虫。大肠弯曲杆菌、多口单胞菌、沙门氏菌和产肠毒素大肠埃希氏菌通常从病例和对照组中分离（分别为22%对25%、10%对11%、6%对9%、10%对6%）；病例和腺病毒的检出率明显高于对照组（分别为9%对0% 18%对3%和16%对2%），而兰氏贾第鞭毛虫的检出率低于对照组。大多数学龄前儿童感染肠道病原体，基于实验室的研究对于了解偏远地区边缘人群肠道病原体的流行病学很重要
The objective was to assess the association of enteric pathogens in diarrheal disease in a remote rural area in Thailand Stool specimens were collected from 236 children aged 3 months to 5 years with acute diarrhea (cases) and from 236 asymptomatic controls Standard microbiologic methods, and enzyme immunoassay for viral pathogens Gtardia and Cryptosporidium, were used to identify enteric pathogens with susceptibility testing by disk diffusion Campylobactei Plestomonas Salmonella and enterotoxigenic Escherichia colt were commonly isolated from cases and controls (22% versus 25%, 10% versus 11%, 6% versus 9%, and 10% versus 6% respectively) Only Shigella rotavirus, and adeno virus were identified significantly more frequently in cases than controls (9% versus 0% 18% versus 3% and 16% versus 2% respectively) whereas Giardia lamblia was detected less often in cases than controls Most pre school children were infested with enteric pathogens, laboratory based studies are Important to understand the epidemiology of enteric patho gens in remote areas among marginal populations