SPIROQUINAZOLINE, A NOVEL SUBSTANCE-P INHIBITOR WITH A NEW CARBON SKELETON, ISOLATED FROM ASPERGILLUS FLAVIPES
SPIROQUINAZOLINE, A NOVEL SUBSTANCE-P INHIBITOR WITH A NEW CARBON SKELETON, ISOLATED FROM ASPERGILLUS FLAVIPES
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DOI：
10.1021/np50106a005
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发表时间：
1994-04-01
影响因子：
5.1
通讯作者：
SUN, HH
中科院分区：
文献类型：
--
作者：
BARROW, CJ;SUN, HH
一种新型 P 物质抑制剂螺喹唑啉 [1] 是从真菌黄曲霉中分离出来的，这种真菌最初是从土壤中获得的。通过光谱数据分析确定了1的结构，并显示1含有一个含有螺碳中心的新碳骨架。从同一培养物提取物中还分离出新的天然产物苯二氮卓二酮 [3] 和已知化合物酰基阿索那宁 [4]、N-苯甲酰基-L-苯丙氨醇和七种二酮哌啶。
A novel substance P inhibitor, spiroquinazoline [1], was isolated from the fungus Asperigillus flavipes, which was originally obtained from soil. The structure of 1 was determined by analysis of spectroscopic data and 1 was shown to contain a new carbon skeleton containing a spiro-carbon center. Also isolated from the same culture extract were the new natural produce, benzodiazepinedione [3], and the known compounds, acyl aszonalenin [4], N-benzoyl-L-phenylalaninol, and seven diketopiperatines.