A form of cell death with some features resembling apoptosis in the amitochondrial unicellular organism Trichomonas vaginalis
A form of cell death with some features resembling apoptosis in the amitochondrial unicellular organism Trichomonas vaginalis
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DOI：
10.1006/excr.2002.5496
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发表时间：
2002-05-15
影响因子：
3.7
通讯作者：
Roseto, A
中科院分区：
文献类型：
--
作者：
Chose, O;Noël, C;Roseto, A
细胞凋亡的标志之一是染色质的降解和伴随的压实。据推测，caspase和caspase非依赖性通路对核凋亡的发展起限速作用。caspase不依赖途径涉及凋亡诱导因子（AIF）并导致DNA断裂和外周染色质凝聚。这两种途径都是线粒体接收、整合并释放各种分子（如细胞色素c和AIF）响应死亡信号激活的结果。事实上，这两种途径都有共同之处，即DNA断裂的终点和启动凋亡事件的分子的线粒体起源。在这里，我们研究了细胞凋亡或细胞凋亡样过程是否存在于缺乏线粒体的单细胞生物中的问题。我们在此表明，在阴道毛滴虫中确实存在一种具有类似细胞凋亡特征的细胞死亡形式。形态学方面的表征涉及到这一事件，以及提供的初步生化数据可能导致新的见解之间的进化关系的不同形式的程序性细胞死亡迄今已确定。(C) 2002 Elsevier Science （USA）。
One of hallmarks of apoptosis is the degradation and concomitant compaction of chromatin. It is assumed that caspases and caspase-independent pathways are rate limiting for the development of nuclear apoptosis. The caspase-independent pathway involves apoptosis-inducing factor (AIF) and leads to DNA fragmentation and peripheral chromatin condensation. Both pathways are the result of activation of death signals that the mitochondrion receives, integrates, and responds to with the release of various molecules (e.g., cytochrome c and AIF). In fact, both pathways have in common the final point of the DNA fragmentation and the mitochondrial origin of molecules that initiate the apoptotic events. Here, we examine the question of whether apoptosis or apoptotic-like processes exist in a unicellular organism that lacks mitochondria. We herein show that a form of cell death with some features resembling apoptosis is indeed present in Trichomonas vaginalis. Characterization of morphological aspects implicated in this event together with the preliminary biochemical data provided may lead to new insight about the evolutionary relationships between the different forms of programmed cell death identified so far. (C) 2002 Elsevier Science (USA).