Polymorphism in the coagulation factor VII gene and the risk of myocardial infarction
Polymorphism in the coagulation factor VII gene and the risk of myocardial infarction
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DOI：
10.1056/nejm199801083380202
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发表时间：
1998-01-08
影响因子：
158.5
通讯作者：
Donati, MB
中科院分区：
文献类型：
--
作者：
Iacoviello, L;Di Castelnuovo, A;Donati, MB
Background High blood levels of coagulation factor VII are associated with a risk of ischemic vascular disease. Although factor VI levels may be genetically determined, the relation between genetic polymorphisms of factor VII, factor VII blood levels, and the risk of myocardial infarction has not been established.Methods We performed a case-control study of 165 patients with familiar myocardial infarction (mean [+/-SD] age, 55+/-9 years) and 225 controls without a personal or family history of cardiovascular disease (mean age, 56+/-8 years). The polymorphisms involving R353Q and hypervariable region 4 of the factor VI gene were studied. Factor VII clotting activity and antigen levels were also measured.Results Patients with the QQ or H7H7 genotype had a decreased risk of myocardia[ infarction (odds ratios, 0.08 [95 percent confidence interval, 0.01 to 0.9] and 0.22 [95 percent confidence interval, 0.08 to 0.63], respectively). For the R353Q polymorphism, the RR genotype was associated with the highest risk, followed by the RQ genotype and then by the QQ genotype (P
