Prevalence and relationship of hypertriglyceridaemic-waist phenotype and type 2 diabetes mellitus among a rural adult Chinese population
Prevalence and relationship of hypertriglyceridaemic-waist phenotype and type 2 diabetes mellitus among a rural adult Chinese population
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中国农村成年人群中高甘油三酯腰部表型与 2 型糖尿病的患病率及其关系
DOI：
10.1017/s1368980019000181
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发表时间：
2019
影响因子：
3.2
通讯作者：
Hu Dongsheng
中科院分区：
文献类型：
--
作者：
Ren Yong Cheng;Liu Yu;Sun Xi Zhuo;Wang Bing Yuan;Liu Yi;Ni Hu;Zhao Yang;Liu Dechen;Liu Xuejiao;Zhang Dongdong;Liu Feiyan;Cheng Cheng;Liu Leilei;Chen Xu;Zhou Qionggui;Zhang Ming;Hu Dongsheng
关于高脂血症腰围（HTGW）表型在农村人群中的患病率和对2型糖尿病（T2 DM）风险的影响的信息有限。我们调查了中国农村成年人中HTGW表型和T2 DM的患病率及其相关性的强度。设置HTGW定义为TAG > 1.7 mmol/l和腰围（WC）。男性≥90 cm，女性≥80 cm。Logistic回归分析得出了T2 DM与HTGW相关风险的校正比值比（aOR）。2013年7 - 8月和2014年7 - 8月在河南省某农村地区随机抽取12 345名22·83-92·58岁的老年人进行调查。（男：15.35%;女：28.88%）和11.79%（男：11.15%;女：12.18%）。在调整性别、年龄、吸烟、饮酒、血压、体力活动和糖尿病家族史后，HTGW增加了T2 DM的风险（aOR; 95% CI）（与正常TAG和WC相比：3·23; CI 2·53，4·13;男性：3·37; 2·30，4·92;女性：3·41; 2·39，4·85）。BMI≥28·0 kg/m2、单纯WC增大、单纯脂代谢紊乱者发生T2 DM的危险性呈上升趋势（aOR=1·31，1·75和2·32）。结论中国农村人群HTGW和T2 DM的患病率已达到警戒水平，HTGW是T2 DM的重要危险因素。
ObjectiveLimited information is available on the prevalence and effect of hypertriglyceridaemic–waist (HTGW) phenotype on the risk of type 2 diabetes mellitus (T2DM) in rural populations.DesignIn the present cross-sectional study, we investigated the prevalence of the HTGW phenotype and T2DM and the strength of their association among rural adults in China.SettingHTGW was defined as TAG >1·7 mmol/l and waist circumference (WC) ≥90 cm for males and ≥80 cm for females. Logistic regression analysis yielded adjusted odds ratios (aOR) relating risk of T2DM with HTGW.ParticipantsAdults (n 12 345) aged 22·83–92·58 years were recruited from July to August of 2013 and July to August of 2014 from a rural area of Henan Province in China.ResultsThe prevalence of HTGW and T2DM was 23·71 % (males: 15·35 %; females: 28·88 %) and 11·79 % (males: 11·15 %; females: 12·18 %), respectively. After adjustment for sex, age, smoking, alcohol drinking, blood pressure, physical activity and diabetic family history, the risk of T2DM (aOR; 95 % CI) was increased with HTGW (v. normal TAG and WC: 3·23; CI 2·53, 4·13; males: 3·37; 2·30, 4·92; females: 3·41; 2·39, 4·85). The risk of T2DM with BMI≥28·0 kg/m2, simple enlarged WC and simple disorders of lipid metabolism showed an increasing tendency (aOR=1·31, 1·75 and 2·32).ConclusionsThe prevalence of HTGW and T2DM has reached an alarming level among rural Chinese people, and HTGW is a significant risk factor for T2DM.