CHARACTERIZATION OF THE LOCOMOTOR STIMULANT ACTION OF NICOTINE IN TOLERANT RATS
CHARACTERIZATION OF THE LOCOMOTOR STIMULANT ACTION OF NICOTINE IN TOLERANT RATS
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DOI：
10.1111/j.1476-5381.1983.tb10733.x
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发表时间：
1983-01-01
影响因子：
7.3
通讯作者：
KUMAR, R
中科院分区：
文献类型：
--
作者：
CLARKE, PBS;KUMAR, R
运动试验(光电池笼)被用来研究大鼠对尼古丁(香烟烟雾的一种有效成分)的耐受性的发展。反复接触该仪器并不影响获得耐受性的速度。(+)-尼古丁(0.4-1.6 mg/kg，S.C.)的比较和(-)-尼古丁(0.1-0.4 mg/kg，S.C.)在耐受性大鼠中发现，(-)-异构体在刺激运动活动方面的效力至少是后者的10倍。南加州大学。甲乙胺(1.0 mg/kg)可完全阻断尼古丁对耐受性大鼠的运动兴奋作用，而氯异丹明(0.01或0.1 mg/kg)可完全阻断耐受性大鼠的运动兴奋作用。只是部分减少了它。当在注射尼古丁后给予甲基戊胺时，尼古丁的运动刺激作用被阻断，尼古丁实际上减少了活动。在实验期间(23-24天)，单次脑室注射氯异丹明(2微克)即可阻断尼古丁的兴奋作用。
Tests of locomotor activity (photocell cages) were used to investigate the development of tolerance to nicotine [an active constituent of cigarette smoke] in rats. Repeated exposure to the apparatus did not influence the rate at which tolerance was acquired. Comparisons of (+)-nicotine (0.4-1.6 mg/kg, s.c.) and (-)-nicotine (0.1-0.4 mg/kg, s.c.) in tolerant rats showed that the (-)-isomer was at least 10 times more potent in stimulating motor activity. S.c. pretreatment with mecamylamine (1.0 mg/kg) completely prevented the locomotor stimulant action of nicotine in tolerant rats, whereas chlorisondamine (0.01 or 0.1 mg/kg s.c.) only partially reduced it. When mecamylamine was given after an injection of nicotine, the locomotor stimulant action of nicotine was blocked, and nicotine actually reduced activity. A single intraventricular dose of chlorisondamine (2 .mu.g) blocked the stimulant actions of nicotine for the duration of the experiment (23-24 days).