Persistent fever in association with infective endocarditis.

Persistent fever in association with infective endocarditis.
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与感染性心内膜炎相关的持续发烧。

DOI:
10.1093/clind/15.6.983
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发表时间:
1992
期刊:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子:
--
通讯作者:
Lowy,FD
Lowy,FD
中科院分区:
--
文献类型:
--
作者:
Blumberg,EA;Robbins,N;Adimora,A;Lowy,FD

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尽管对心内膜炎进行了足够的抗菌治疗,但持续发烧可能是一个不祥的征兆。为了评估持续发烧在这种情况下的重要性,我们回顾了阿尔伯特·爱因斯坦医学院三家附属医院的患者记录。确定了26例患者,27次心内膜炎和在适当的抗菌治疗下持续2周的发热,并与26例心内膜炎但没有持续发热的匹配队列进行了比较。前者发热持续时间的中位数为35天。心脏感染导致其中13名患者发烧,其中7名患者有心肌脓肿。其他感染原因包括药物治疗、病原体在医院的传播和肺血栓。16名患者需要心脏手术(7例紧急情况下),而只有2名对照组接受了这样的手术(P<.001)。22名持续发烧的患者和5名对照组发生了医院并发症(P<.001)。6名发烧患者死亡,5名患者死于心内膜炎相关并发症。因此,持续发烧往往预示着复杂的心内膜炎。我们提出了一种评估受这种情况影响的患者的方法。
Fever persisting despite adequate antimicrobial therapy for endocarditis can be an ominous sign. To evaluate the significance of persistent fever in this situation, we reviewed the records of patients at three hospital affiliates of Albert Einstein College of Medicine. Twenty-six patients with 27 episodes of endocarditis and fever lasting for ⩾ 2 weeks despite appropriate antimicrobial therapy were identified and compared with a matched cohort of 26 patients with endocarditis but without prolonged fever. The median duration of fever in the former group was 35 days. Cardiac infection caused fever in 13 of these patients, seven of whom had myocardial abscesses. Additional causes of infection included drug treatment, nosocomial transmission of pathogens, and pulmonary emboli. Sixteen patients required cardiac surgery (seven on an emergent basis), whereas only two controls underwent such a procedure (P< .001). Twenty-two patients with persistent fever and five controls developed nosocomial complications (P< .001). Six patients with fever died, five from endocarditis-related complications. Thus persistent fever often indicates complicated endocarditis. We present an approach for the evaluation of the patients affected by this condition.
人工瓣膜心内膜炎38例分析
DOI: 10.1161/01.cir.48.2.365
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