EFFECT OF COPULATORY BEHAVIOR ON HORMONAL CHANGE IN FEMALE RAT PRIOR TO IMPLANTATION
EFFECT OF COPULATORY BEHAVIOR ON HORMONAL CHANGE IN FEMALE RAT PRIOR TO IMPLANTATION
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DOI：
10.1016/0031-9384(70)90155-1
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发表时间：
1970-01-01
影响因子：
2.9
通讯作者：
GOY, RW
中科院分区：
文献类型：
--
作者：
ADLER, NT;RESKO, JA;GOY, RW
雌性大鼠发情时，其全身血浆中孕酮的浓度与其接受的交配刺激量成正比。在交配后6小时内，女性接受超过9次插入（高插入组）有显着较高的数量，这种激素在他们的血液中比女性没有接受交配刺激（对照组）。高导入组的雌性在交配后的四天内表现出孕酮浓度的稳定增加，而接受少量导入（低导入组）或不导入（对照组）的雌性则没有表现出这种增加。除了孕酮，雌性大鼠还分泌第二种较弱的妊娠激素：20α-OH-孕甾-4-烯-3-酮。交配后第4天，高导入组孕酮与20α-OH-孕甾-4-烯-3-酮的比值为1.10，而低导入组为0.43，对照组为0.21。因此，来自雄性大鼠的交配插入的足够刺激在雌性中启动神经内分泌反射;该反射的结果是在性交后不久雌性中孕酮的浓度升高，随后是妊娠特征的维持分泌。
The concentration of progesterone in systemic plasma of female rats was proportional to the amount of copulatory stimulation they received when they were in heat. Within 6 hr after mating, females receiving more than 9 intromissions (High Intromission Group) had significantly higher quantities of this hormone in their blood than did females receiving no copulatory stimulation (Control Group). Females in the High Intromission Group showed steadily increasing concentrations of progesterone over the four days following mating, while females receiving a small number of intromissions (Low Intromission Group) or no intromissions (Control Group) did not show this increase. In addition to progesterone, the female rat is known to secrete a second, weaker, gestational hormone: 20α-OH-pregn-4-ene-3-one. On the fourth day after mating, the ratio of progesterone to 20α-OH-pregn-4-ene-3-one in the High Intromission Group was 1.10 compared to 0.43 for the Low Intromission Group and 0.21 for the Control Group. Thus, sufficient stimulation from the male rat's copulatory intromissions initiates a neuro-endocrine reflex in the female; the result of this reflex is an elevated concentration of progesterone in the female soon after coitus, followed by the maintained secretion characteristic of pregnancy.