Dietary anthocyanin intake and age-related decline in lung function: longitudinal findings from the VA Normative Aging Study
Dietary anthocyanin intake and age-related decline in lung function: longitudinal findings from the VA Normative Aging Study
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DOI：
10.3945/ajcn.115.121467
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发表时间：
2016-02-01
影响因子：
7.1
通讯作者：
Schwartz, Joel
中科院分区：
文献类型：
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作者：
Mehta, Amar J.;Cassidy, Aedin;Schwartz, Joel
目的：我们调查了习惯性饮食中存在的不同类黄酮是否与老年人肺功能随时间的有益变化有关。设计：这项纵向分析来自退伍军人事务部(VA)规范老龄化研究的839名参与者，他们的肺功能[S的用力呼气量(FEV1)和用力肺活量(FVC)]在1992年至2008年期间进行了2次和最多5次测量(n=2623)。主要类黄酮亚类(花青素、黄烷酮、黄烷醇-3-醇、黄酮醇、黄酮类和聚合物)的年平均摄入量是根据每次就诊时的食物频率问卷计算的。在调整了生活方式和饮食因素后，我们在线性混合效应回归模型中估计了与每个类黄酮亚类相关的肺功能年变化的调整后差异。结果：花青素摄入量与年龄相关的肺功能下降之间存在强烈的负相关。与饮食和非饮食危险因素无关，与第一个四分之一分位数的参与者相比，第四个四分之一分位数的参与者的FEV1和FVC下降的速度分别慢了23.6mIJy(95%CI：16.6，30.7)和37.3mIJy(95%CI：27.8，46.8)(P-Trend<；0.0001)。观察到的花青素摄入的保护性关联在现在/以前吸烟者和从不吸烟者中都存在。与不摄入或极低摄入量相比，每周摄入2份富含花青素的蓝苯类化合物，FEV1和FVC的下降速度分别慢22.5(95%CI：10.8，34.2)和37.9(95%CI：22.1，53.7)毫升/年。结论：在以老年男性为主的纵向样本中，与年龄相关的肺功能下降的缓解与饮食中较高的花青素摄入量有关。需要进一步的前瞻性研究来证实这些新的联系。
Background: It is unknown whether habitual intake of dietary flavonoids, known for their antioxidative and anti-inflammatory properties, affects longitudinal change in lung function.Objective: We investigated whether different flavonoid subclasses present in the habitual diet were associated with beneficial changes in lung function over time in the elderly.Design: This longitudinal analysis included 839 participants from the VA (Veterans Affairs) Normative Aging Study whose lung function [forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC)] was measured at 2 and up to 5 visits between 1992 and 2008 (n = 2623 measurements). Yearly average intake of major flavonoid subclasses (anthocyanins, flavanones, flavan-3-ols, flavonols, flavones, and polymers) was calculated from food-frequency questionnaires at each visit. We estimated adjusted differences in annual change in lung function associated with each flavonoid subclass, categorized into quartiles, in linear mixed-effects regression models after adjustment for lifestyle and dietary confounders.Results: Strong inverse associations were found between anthocyanin intake and age-related decline in lung function. Independent of dietary and nondietary risk factors, slower rates of FEV1 and FVC decline by 23.6 (95% CI: 16.6, 30.7) and 37.3 (95% CI: 27.8, 46.8) mIJy, respectively, were observed in participants in the fourth quartile of intake compared with participants in the first quartile (P-trend < 0.0001). The protective associations observed for anthocyanin intake were present in both current/former and never smokers. Compared with no or very low intakes, an intake of >= 2 servings of anthocyanin-rich bluebenies/wk was associated with slower decline in FEV1 and FVC by 22.5 (95% CI: 10.8, 34.2) and 37.9 (95% CI: 22.1, 53.7) mL/y, respectively. To a lesser extent, higher flavan-3-ol intake was also associated with slower lung function decline.Conclusions: An attenuation of age-related lung function decline was associated with higher dietary anthocyanin intake in this longitudinal sample of predominantly elderly men. Further prospective studies are needed to confirm these novel associations.