Does Inflammation Mediate the Association Between Obesity and Insulin Resistance?
Does Inflammation Mediate the Association Between Obesity and Insulin Resistance?
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DOI：
10.1007/s10753-016-0329-z
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发表时间：
2016-06-01
期刊：
影响因子：
5.1
通讯作者：
Convit, Antonio
中科院分区：
文献类型：
--
作者：
Adabimohazab, Razieh;Garfinkel, Amanda;Convit, Antonio
在成人肥胖症中，低度全身性炎症被认为是胰岛素抵抗（IR）发病机制中的重要步骤。肥胖和炎症之间的联系在青少年中不太明确。在这里，我们确定的重要性，炎症在IR肥胖青少年利用随机森林（RF）分类或调解分析方法。炎症平衡评分由8个促炎和抗炎标记物组成，以及大多数单个炎症标记物在瘦型和超重/肥胖型之间存在显著差异。相比之下，脂联素是RF选择作为IR预测因子的唯一个体标志物，平衡评分仅显示中等至低的重要性评分。无论是脂联素，也没有炎症平衡评分被发现调解肥胖和IR之间的关系。这些研究结果不支持的前提下，低度全身性炎症是一个关键的IR在人类的表达。前瞻性纵向研究应证实这些发现。
In adult obesity, low-grade systemic inflammation is considered an important step in the pathogenesis of insulin resistance (IR). The association between obesity and inflammation is less well established in adolescents. Here, we ascertain the importance of inflammation in IR among obese adolescents by utilizing either random forest (RF) classification or mediation analysis approaches. The inflammation balance score, composed of eight pro- and anti-inflammatory makers, as well as most of the individual inflammatory markers differed significantly between lean and overweight/obese. In contrast, adiponectin was the only individual marker selected as a predictor of IR by RF, and the balance score only revealed a medium-to-low importance score. Neither adiponectin nor the inflammation balance score was found to mediate the relationship between obesity and IR. These findings do not support the premise that low-grade systemic inflammation is a key for the expression of IR in the human. Prospective longitudinal studies should confirm these findings.