PROMOTION OF THE WHITTEN EFFECT IN FEMALE MICE BY SYNTHETIC ANALOGS OF MALE URINARY CONSTITUENTS
PROMOTION OF THE WHITTEN EFFECT IN FEMALE MICE BY SYNTHETIC ANALOGS OF MALE URINARY CONSTITUENTS
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DOI：
10.1073/pnas.83.12.4576
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发表时间：
1986-06-01
影响因子：
11.1
通讯作者：
NOVOTNY, M
中科院分区：
文献类型：
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作者：
JEMIOLO, B;HARVEY, S;NOVOTNY, M
合成了雄性小鼠尿液中的两种挥发性成分2-（仲丁基）-4，5-二氢噻唑和脱氢-exobrevicomin，并测试了它们诱导雌性小鼠发情周期的能力（Whitten效应）。通过暴露于正常雄性尿液，消除了对雌性分组导致的卵巢周期活动的抑制。当以适当浓度将合成化合物一起添加到去势雄性的（先前无活性的）尿液中，甚至添加到水中时，发现与正常雄性尿液一样有效。合成化合物的作用似乎减弱为单一笼雌性。
Two volatile constituents of male mouse urine, 2-(sec-butyl)-4,5-dihydrothiazole and dehydro-exobrevicomin, were synthesized and tested for their ability to induce estrous cycle in female mice (the Whitten effect). The suppression of ovarian cycling activity that resulted from grouping the females was abolished by exposure to normal male urine. The synthetic compounds, when added together in appropriate concentrations to the (previously inactive) urine of castrated males, or even to water, were found to be as effective as normal male urine. The action of the synthetic compounds appears attenuated for singly caged females.