Cytomegalovirus Colitis, Cytomegalovirus Hepatitis and Systemic Cytomegalovirus Infection: Common Features and Differences.
Cytomegalovirus Colitis, Cytomegalovirus Hepatitis and Systemic Cytomegalovirus Infection: Common Features and Differences.
复制标题
巨细胞病毒结肠炎、巨细胞病毒肝炎和全身性巨细胞病毒感染：共同特征和差异。
DOI：
10.1159/000443198
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发表时间：
2016
影响因子：
--
通讯作者：
Herfarth,Hans
中科院分区：
文献类型：
--
作者：
Nakase,Hiroshi;Herfarth,Hans
巨细胞病毒（CMV）是一种普遍存在的人类疱疹病毒，其在通常无症状的原发感染后，建立终身潜伏感染，其可以在免疫活性和免疫抑制的携带者中周期性地重新激活。虽然在怀疑CMV再激活的情况下的诊断方法是明确的，但抗病毒治疗的适应症通常只能在患者的器官受累程度、免疫状态和合并症的背景下进行。本文综述了CMV再激活的流行病学、诊断和治疗，重点关注炎症性肠病以及亚洲和西方世界可能不同的诊断和治疗方法。
Cytomegalovirus (CMV) is a ubiquitous human herpes virus, which, after often asymptomatic primary infection, establishes a lifelong latent infection that can periodically be reactivated in both immunocompetent and immunosuppressed carriers. Whereas the diagnostic approach in case of a suspicion of CMV reactivation is well defined, the indication for antiviral therapy can often only be made in the context of an extent of organ involvement, the immune status, and comorbidities of the patient. This article reviews the epidemiology, diagnosis, and therapy of CMV reactivation with a focus on inflammatory bowel diseases and potentially different diagnostic and therapeutic approaches in Asia and the Western world.