Total gastrectomy-induced reductions in food intake and weight are counteracted by rikkunshito by attenuating glucagon-like peptide-1 elevation in rats.
Total gastrectomy-induced reductions in food intake and weight are counteracted by rikkunshito by attenuating glucagon-like peptide-1 elevation in rats.
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rikkunshito 通过减弱大鼠胰高血糖素样肽-1 的升高来抵消全胃切除术引起的食物摄入量和体重的减少。
DOI：
10.1016/j.surg.2015.12.003
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发表时间：
2016
期刊：
影响因子：
3.8
通讯作者：
taguchi Masanobu
中科院分区：
文献类型：
--
作者：
Hodaka Yamada;Masashi Yoshida;Kiyonori Ito;Katsuya Dezaki;Toshihiko Yada;San-e Ishikawa;Masafumi Kakei;taguchi Masanobu
背景：胃癌患者全胃切除术后食欲和体重下降，导致生活质量下降，死亡率增加，可能需要停止辅助化疗。本研究的目的是确定日本草药立解是否会增加大鼠胃切除术后的食物摄入量和体重。方法小鼠胃切除术后行roux-en-Y重建或假手术，术后第3天起予利健液治疗14 d。测量每日食物摄入量、体重、血浆胰高血糖素样肽-1 （GLP-1）和胃饥饿素水平。一项测量胃癌全胃切除术患者术前和术后血浆GLP-1水平的初步研究。结果胃切除术后大鼠给予利坤泻可显著增加其摄食量和体重，并持续2周以上。与假手术动物相比，胃切除术后空腹和餐后血浆GLP-1水平均显著升高。胃切除术后大鼠血清GLP-1水平升高明显受到利健茶的抑制。利昆之汤对胃切除术后血浆胃促生长素水平无显著影响。GLP-1受体拮抗剂治疗显著改善胃切除术后的食物摄入量和体重。胃癌患者术后第1天空腹血浆GLP-1水平明显升高。结论利康泻可抑制全胃切除术后大鼠血浆GLP-1水平，与减食量和体重恢复有关。
BackgroundDecrease in appetite and weight after total gastrectomy in patients with gastric cancer leads to a decrease in quality of life, increased mortality, and may necessitate discontinuation of adjuvant chemotherapy. The aim of this study is to determine whether rikkunshito, a Japanese herbal medicine, increases food intake and weight after gastrectomy in rats.MethodsMale rats underwent gastrectomy followed by roux-en-Y reconstruction or sham operation and were then treated with rikkunshito for 14 days starting on postoperative day 3. Daily food intake, weight, plasma glucagon-like peptide-1 (GLP-1), and ghrelin levels were measured. A pilot study to measure pre- and postoperative plasma GLP-1 levels was conducted in patients who underwent total gastrectomy for gastric cancer.ResultsAdministration of rikkunshito after gastrectomy in rats significantly increased food intake and weight, which continued for at least 2 weeks after treatment. Both fasting and postprandial plasma GLP-1 levels were increased markedly after gastrectomy compared with sham-operated animals. Increased GLP-1 levels in rats after gastrectomy were suppressed markedly by rikkunshito. rikkunshito had no significant effect on plasma ghrelin levels after gastrectomy. Treatment with a GLP-1 receptor antagonist significantly improved food intake and weight after gastrectomy. Plasma fasting GLP-1 levels in patients with gastric cancer were increased greatly after gastrectomy on postoperative day 1.ConclusionAdministration of rikkunshito suppresses plasma GLP-1 levels after total gastrectomy, which is associated with recovery from reduced food intake and weight in rats.
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美国印刷 版权所有 © 1999 内分泌学会 迷走神经在调节近端营养诱导的胰高血糖素样肽-1 分泌中的作用*
DOI：
--
发表时间：
--
期刊：
影响因子：
--
作者：
S. Ritter;T. Dinh
通讯作者：
T. Dinh
影响因子：
4.8
作者：
Lovshin, J;Estall, J;Drucker, DJ
通讯作者：
Drucker, DJ
胆囊收缩素是大鼠全胃切除术后食物摄入减少和体重减轻的部分原因。
影响因子：
3
作者：
T. Zittel;B. V. Elm;Robert K. Teichmann;Helen E. Rabould;Horst D. Becker
通讯作者：
Horst D. Becker
血清素受体阻断会增加大鼠全胃切除术后的食物摄入量和体重。
影响因子：
2.2
作者：
T. Zittel;J. Glatzle;T. Weimar;Steffen Kless;H. Becker;E. Jehle
通讯作者：
E. Jehle
根治性胃切除术后胃腺癌患者的生活质量
影响因子：
2.6
作者：
Chew‐Wun Wu;M. Hsieh;S. Lo;W. Lui;F. P'eng
通讯作者：
F. P'eng