Sleep Apnea and its Association with the Stress System, Inflammation, Insulin Resistance and Visceral Obesity
Sleep Apnea and its Association with the Stress System, Inflammation, Insulin Resistance and Visceral Obesity
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DOI：
10.1016/j.jsmc.2007.04.003
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发表时间：
2007-06-01
影响因子：
2.8
通讯作者：
Pejovic, Slobodanka
中科院分区：
文献类型：
--
作者：
Trakada, Georgia;Chrousos, George P.;Pejovic, Slobodanka
阻塞性睡眠呼吸暂停（OSA）是一种慢性疾病，其特征是睡眠期间上呼吸道反复塌陷，导致严重的低氧血症和反复从睡眠中醒来。阻塞性睡眠呼吸暂停与相当高的发病率和死亡率有关。在普通人群随机抽样中，4%的成年男性和2%的成年女性符合目前诊断睡眠呼吸暂停的临床和多导睡眠图标准。肥胖是阻塞性睡眠呼吸暂停最重要的可逆危险因素。在这篇文章中，作者回顾了过去10年来积累的关于睡眠呼吸暂停及其与应激系统、炎症、胰岛素抵抗和内脏肥胖的关系的知识。
Obstructive sleep apnea (OSA) is a chronic condition characterized by repetitive collapse of the upper airway during sleep leading to significant hypoxemia and recurrent arousals from sleep. OSA is associated with considerable morbidity and mortality. Four percent of adult men and two percent of adult women in general population random samples meet the current clinical and polysomnographic criteria for the diagnosis of sleep apnea. Obesity is the most important reversible risk factor for OSA. In this article, the authors review knowledge accumulated during the last 10 years about sleep apnea and its association with the stress system, inflammation, insulin resistance and visceral obesity.