Recent Strategies in Nickel-Catalyzed C–H Bond Functionalization for Nitrogen-Containing Heterocycles
Recent Strategies in Nickel-Catalyzed C–H Bond Functionalization for Nitrogen-Containing Heterocycles
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DOI：
10.3390/catal12101163
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发表时间：
2022-10
期刊：
影响因子：
3.9
通讯作者：
Ker-Ming Yang;Zhi Li;Qing-Tao Hu;Mazen Elsaid;Chong Liu;Jun Chen;H. Ge
中科院分区：
文献类型：
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作者：
Ker-Ming Yang;Zhi Li;Qing-Tao Hu;Mazen Elsaid;Chong Liu;Jun Chen;H. Ge
氮杂环化合物广泛存在于天然产物、药物、有机材料和许多功能分子中。在现有的合成方法中，过渡金属催化的C-H官能化反应由于其简单、原子经济性高、原料易得等优点，近年来受到了广泛的关注。在通过C-H官能化合成N-杂环的领域中，镍被认为是最重要的催化剂之一。本文将介绍2008年至2021年镍催化的分子内和分子间N-杂环合成途径。
N-heterocycles are ubiquitous in natural products, pharmaceuticals, organic materials, and numerous functional molecules. Among the current synthetic approaches, transition metal-catalyzed C–H functionalization has gained considerable attention in recent years due to its advantages of simplicity, high atomic economy, and the ready availability of starting materials. In the field of N-heterocycle synthesis via C–H functionalization, nickel has been recognized as one of the most important catalysts. In this review, we will introduce nickel-catalyzed intramolecular and intermolecular pathways for N-heterocycle synthesis from 2008 to 2021.