Neuron activation, degeneration and death in the hippocampus of mice after pilocarpine induced status epilepticus.
Neuron activation, degeneration and death in the hippocampus of mice after pilocarpine induced status epilepticus.
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DOI：
10.3969/j.issn.1672-7347.2011.11.007
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发表时间：
2011-11-01
期刊：
影响因子：
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通讯作者：
Liu, Yong
中科院分区：
文献类型：
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作者：
Liu, Jianxin;Tang, Fengru;Liu, Yong
目的：目的：探讨癫痫持续状态后海马神经元激活、变性和死亡的发生及其相互关系。方法：采用匹罗卡品致痫后不同时间点的CFV、FluoroJade B和c-Fos染色。结果：癫痫持续状态后1 h、2 h和1 d，齿状回颗粒层c-Fos阳性神经元明显增多（P < 0.05），海马齿状回颗粒层c-Fos阳性神经元明显增多（P < 0.05），海马齿状回颗粒层c-Fos阳性神经元明显增多（P < 0.01），海马齿状回颗粒层c-Fos阳性神经元明显增多（P < 0.05），海马齿状回颗粒层c-Fos阳性神经元明显增多（P < 0.05），海马齿状回颗粒层c-Fos阳性神经元明显增多（P < 0.05）。
OBJECTIVE: To examine the occurrence of neuron activation, neurodegeneraion and cell death, and the correlation among them in the hippocampus after status epilepticus.METHODS: CFV, Fluoro Jade B and c-Fos staining were done at multiple time points after pilocarpine induced status epilepticus.RESULTS: In the stratum granulosum of dentate gyrus, c-Fos positive neurons increased significantly at 1 h, 2 h and 1 d after status epilepticus (P