Portal venous velocity in the follow-up of patients with biliary atresia after Kasai portoenterostomy.
Portal venous velocity in the follow-up of patients with biliary atresia after Kasai portoenterostomy.
复制标题
Kasai 门肠造口术后胆道闭锁患者随访中的门静脉流速。
DOI：
10.1053/jpsu.2002.32892
复制
发表时间：
2002
影响因子：
2.4
通讯作者：
W. Peh
中科院分区：
文献类型：
--
作者：
P. Khong;C. Ooi;H. Saing;K. Chan;W. H. Wong;P. Tam;H. Han;W. Peh
背景/目的
肝移植是加塞门肠吻合术（PE）失败的胆道闭锁（BA）患者的唯一治疗选择。肝移植的指征和时机是重要的管理问题。本研究的目的是评估门静脉血流速度（PVV）和临床和肝功能生化指标之间的关系，并检查PVV在这些患者的术后监测的作用。
方法
29名因BA而发生PE的儿童（平均年龄8岁4个月）接受多普勒超声检查以评估PVV。使用回归分析，这些结果与肝功能生化指标相关。使用Mann-Whitney检验检测Child-Pugh A组与Child-Pugh B和C组合并患者之间PVV的任何显著差异。
结果
Child-Pugh A组和联合Child-Pugh B和C组的平均+/- SD PVV分别为17.1 cm/s +/- 8.9 cm/s和10.2 cm/s +/- 3.3 cm/s，该差异具有统计学显著性（P = 0.037）。
结论
多普勒超声检测PVV可为临床及生化指标评价BA患者的肝功能状态提供可靠的依据。它在这些患者的术后监测中的使用有助于确定肝移植的需要和时机。
BACKGROUND/PURPOSE
Liver transplantation is the only therapeutic option for biliary atresia (BA) patients with failed Kasai portoenterostomy (PE). The indication for and timing of liver transplantation in these patients are important management issues. The aims of this study are to evaluate the relationship between portal venous velocity (PVV) and clinical and biochemical indicators of liver function in BA, and to examine the role of PVV in the postoperative surveillance of these patients.
METHODS
Twenty-nine children (mean age, 8 years 4 months) who had PE for BA underwent Doppler ultrasonography to evaluate PVV. Using regression analysis, these findings were correlated with biochemical indicators of liver function. The Mann-Whitney test was used to detect any significant differences in PVV between the Child-Pugh A group and combined Child-Pugh B and C group patients.
RESULTS
The mean +/- SD PVV for the Child-Pugh A group and the combined Child-Pugh B and C group was 17.1 cm/s +/- 8.9 cm/s and 10.2 cm/s +/- 3.3 cm/s, respectively, and this difference was statistically significant (P =.037).
CONCLUSIONS
Doppler ultrasonography measurement of PVV provides adjunctive information to the clinical and biochemical assessment of the liver function status in BA. Its use in the postoperative surveillance of these patients is helpful in identifying the need for and in timing of liver transplantation.