Mesoporous polydopamine carrying sorafenib and SPIO nanoparticles for MRI-guided ferroptosis cancer therapy
Mesoporous polydopamine carrying sorafenib and SPIO nanoparticles for MRI-guided ferroptosis cancer therapy
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DOI：
10.1016/j.jconrel.2020.01.048
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发表时间：
2020-04-10
影响因子：
10.8
通讯作者：
Cao, Zhong
中科院分区：
文献类型：
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作者：
Guan, Qingqing;Guo, Ruomi;Cao, Zhong
铁基纳米材料作为主要的铁中毒诱导平台更有前途，因为铁本身是芬顿反应产生ROS的关键组分。然而，Fe剂量需要非常高，以便使用SPIO NP诱导基于铁凋亡的癌症治疗。因此，通过将铁基纳米材料与其他组分和治疗方式相结合来增强基于铁凋亡的癌症治疗的功效仍然是一个巨大的挑战。在这项研究中，索拉非尼（SRF）和超小的SPIO纳米粒子装载到介孔和MPDA纳米粒子的表面上，以形成SRF@MPDA-SPIO纳米粒子。SPIO负载为系统提供铁供应，使系统MRI可见。同时，SRF能够在较低的Fe剂量下诱导癌细胞的铁凋亡。此外，MPDA NP在激光照射时产生的热量提供了适度的PTT以增强铁凋亡效应。SRF@MPDA-SPIO具有良好的生物相容性，可用于体内应用，并可通过铁凋亡和光热疗法的组合进行上级抗癌治疗。
Iron-based nanomaterials as the main ferroptosis-inducing platforms are more promising because iron itself is a key component in the Fenton reaction to produce ROS. However, the Fe dose needs to be very high in order to induce ferroptosis-based cancer treatment using the SPIO NPs. Therefore, it is still of great challenge to enhance the efficacy of ferroptosis-based cancer therapy by associating the iron-based nanomaterials with other components and therapeutic modalities. In this study, sorafenib (SRF) and ultrasmall SPIO nanoparticles were loaded into the mesopores and onto the surface of MPDA NPs to form SRF@MPDA-SPIO nanoparticles. SPIO loading endowed the system with iron-supply for ferroptosis and made the system MRI-visible. Meanwhile, SRF was able to induce ferroptosis in cancer cells with lower Fe dose. Furthermore, the heat generated by MPDA NPs upon laser irradiation offered a moderate PTT to boost the ferroptosis effect. The SRF@MPDA-SPIO exhibited bio-compatibility highly desirable for in vivo application and superior anticancer therapy via the combination of ferroptosis and photothermal therapy.