Penicillixanthone A, a marine-derived dual-coreceptor antagonist as anti-HIV-1 agent
Penicillixanthone A, a marine-derived dual-coreceptor antagonist as anti-HIV-1 agent
复制标题
Penicillixanthone A，一种海洋来源的双辅助受体拮抗剂，作为抗 HIV-1 药物。
DOI：
10.1080/14786419.2017.1416376
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发表时间：
2019-05-19
影响因子：
2.2
通讯作者：
Zhou, Xuefeng
中科院分区：
文献类型：
--
作者：
Tan, Suiyi;Yang, Bin;Zhou, Xuefeng
Marine micro-organisms have been proven to be excellent sources of bioactive compounds against HIV-1. Several natural products obtained from marine-derived Aspergillus fungi were screened for their activities to inhibit HIV-1 infection. Penicillixanthone A (PXA), a natural xanthone dimer from jellyfish-derived fungus Aspergillus fumigates, displayed potent anti-HIV-1 activity by inhibiting infection against CCR5-tropic HIV-1 SF162 and CXCR4-tropic HIV-1 NL4-3, with IC50 of 0.36 and 0.26 mu M, respectively. Molecular docking study was conducted to understand the possible binding mode of PXA with the CCR5/CXCR4. The results revealed that, the marine-derived PXA, as a CCR5/CXCR4 dual-coreceptor antagonist, presents a new type of potential lead product for the development of anti-HIV therapeutics.
