Effect of ropinirole on sleep onset: A randomized, placebo-controlled study in healthy volunteers
Effect of ropinirole on sleep onset: A randomized, placebo-controlled study in healthy volunteers
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DOI：
10.1212/wnl.58.3.460
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发表时间：
2002-02-12
期刊：
影响因子：
9.9
通讯作者：
Rascol, O
中科院分区：
文献类型：
--
作者：
Ferreira, JJ;Galitzky, M;Rascol, O
嗜睡和“睡眠发作”已被报道为几种抗帕金森病药物的不良反应。作者在20名健康志愿者中进行了一项安慰剂对照、随机、双盲、交叉研究，使用多系统潜伏期试验（MPERT）作为主要结局，罗匹尼罗缩短了人类的睡眠时间。罗匹尼罗治疗与白天快速眼动（REM）睡眠发作无关。
Somnolence and "sleep attacks" have been reported as an adverse effect of several antiparkinsonian drugs. The authors document, in a placebo-controlled, randomized; double-blind, crossover study performed in 20 healthy volunteers, using the Multiple System Latency Test (MSLT) as primary outcome, that ropinirole reduces time to sleep onset in humans. Ropinirole therapy was not associated with daytime episodes of rapid eyes movement (REM) sleep.