Biofunctional chemistry and reactivity of biogenic acrolein for cancer diagnosis and therapy
Biofunctional chemistry and reactivity of biogenic acrolein for cancer diagnosis and therapy
复制标题
生物丙烯醛在癌症诊断和治疗中的生物功能化学和反应性
DOI：
10.1039/d1cc03590h
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发表时间：
2021
影响因子：
4.9
通讯作者：
Tanaka Katsunori
中科院分区：
文献类型：
--
作者：
Pradipta Ambara R.;Tanaka Katsunori
丙烯醛作为生物标记物在各种氧化应激相关疾病中具有极好的潜力，包括癌症、阿尔茨海默氏症、帕金森氏症和炎症性疾病。因此，靶向和可视化生物系统中的丙烯醛的直接方法可能是为诊断和治疗目的提供工具所必需的。以前，我们发现芳基叠氮化合物和丙烯醛之间的1，3-偶极环加成反应在没有催化剂的情况下进行，得到α-重氮酮基衍生物。该反应即使在生理条件下也具有很高的反应活性和选择性。我们已经成功地利用该反应作为一种可靠的方法来检测癌细胞产生的丙烯醛。这篇综述讨论了内源性丙烯醛与芳基叠氮反应在(1)在保乳手术中区分乳腺癌和正常组织以及(2)在小鼠模型中通过选择性前药激活治疗癌症而不引起不良反应的应用。这些方法在保乳手术中具有潜在的临床应用价值，在癌症治疗中具有很大的优势。
Acrolein holds excellent potential as a biomarker in various oxidative stress-related diseases, including cancer, Alzheimer's, Parkinson's, and inflammatory disorders. Consequently, a direct method to target and visualize acrolein in biological systems might be essential to provide tools for diagnosis and therapeutic purposes. Previously, we discovered 1,3-dipolar cycloaddition between aryl azides and acrolein, which proceeds without a catalyst to give α-diazocarbonyl derivatives. The reaction proceeds with high reactivity and selectivity even under physiological conditions. We have successfully utilized the reaction as a robust method for detecting acrolein generated by cancer cells. This review discusses the utilization of the endogenous acrolein reaction with aryl azide to (1) distinguish breast cancer from normal tissue during breast-conserving surgery and (2) treat cancer through selective prodrug activation in a mouse model without causing adverse effects. The methods have potential clinical application for breast-conserving surgery and are highly advantageous for cancer therapy.