Coinfection of macaques with simian immunodeficiency virus and simian T cell leukemia virus type I: Effects on virus burdens and disease progression
Coinfection of macaques with simian immunodeficiency virus and simian T cell leukemia virus type I: Effects on virus burdens and disease progression
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DOI：
10.1086/314627
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发表时间：
1999-03-01
影响因子：
6.4
通讯作者：
Li, YX
中科院分区：
文献类型：
--
作者：
Fultz, PN;McGinn, T;Li, YX
为了验证人类免疫缺陷病毒(HIV)和人类T细胞白血病/淋巴瘤病毒I型或II型(HTLV-I或-II)混合感染会加速进展为艾滋病的假设，将SIV和STLV-I接种给猪尾猕猴。在对单独感染和双重感染的猕猴进行2年的随访期间，没有发现SN负担、疾病发作或存活方面的差异。然而，在第一只死于艾滋病的混合感染猕猴中(感染后1年)，50%的CD4(+)和CD8(+)淋巴细胞表达CD25。基于自然感染期间HTLV-I和STLV-I相关疾病的低发生率，这一肿瘤疾病的早期证据是意想不到的。虽然这些结果表明，SIV和STLV-I混合感染对免疫缺陷疾病的发展没有影响，但它们确实建立了一个可靠的STLV-I持续感染猕猴模型。
To test the hypothesis that coinfection with human immunodeficiency virus (HIV) and human T cell leukemia/lymphoma virus types I or II (HTLV-I or -II) accelerates progression to AIDS, pig-tailed macaques were inoculated with the simian counterparts, SIV and STLV-I. During 2 years of follow-up of singly and dually infected macaques, no differences in SN burdens, onset of disease, or survival were detected. However, in the first coinfected macaque that died of AIDS (1 year after infection), >50% of CD4(+) and CD8(+) lymphocytes expressed CD25. On the basis of the low incidence of HTLV-I- and STLV-I-associated disease during natural infections, this early evidence of neoplastic disease was unexpected. While these results demonstrate that coinfection with SIV and STLV-I has no influence on the development of immunodeficiency disease, they do establish a reliable macaque model of persistent STLV-I infection.