Muscle fiber type composition and effects of vocal fold immobilization on the two compartments of the human posterior cricoarytenoid: A case study of four patients
Muscle fiber type composition and effects of vocal fold immobilization on the two compartments of the human posterior cricoarytenoid: A case study of four patients
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DOI：
10.1016/s0892-1997(03)00027-4
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发表时间：
2003-03-01
期刊：
影响因子：
2.2
通讯作者：
Sciote, JJ
中科院分区：
文献类型：
--
作者：
Brandon, CA;Rosen, C;Sciote, JJ
人环杓后肌（PCA）分为两个隔室，即垂直腹和水平腹，它们含有肌球蛋白重链（MyHC）组成的差异。本研究利用免疫组织化学技术对整个PCA样本进行分析，更全面地描述了PCA整个腹部的纤维类型组成。4例患者提供了完整的PCA样本，包括其左右两侧的两个腔室；两例单侧声带固定。水平腹部有80%的慢速（I型）纤维和20%的快速（II型）纤维。垂直腹部含有等量的慢纤维和快纤维（类似于55%:45%）；清楚地区分两个隔间。在正常和受影响的受试者中也存在肌纤维萎缩和纤维类型分组；没有明确证实声带固定的临床表现。需要进一步研究单侧声带固定患者的PCA肌肉。
The human posterior cricoarytenoid (PCA) muscle is divided into two compartments, the vertical and horizontal bellies, which contain differences in their myosin heavy chain (MyHC) composition. Using immunohistochemical techniques on whole PCA samples, this study provides a more thorough description of the fiber type composition of entire bellies of the PCA. Four patients provided complete PCA samples containing both compartments of their right and left sides; two with unilaterally immobilized vocal folds. The horizontal belly had 80% slow (type I) fibers and 20% fast (type II) fibers. The vertical belly contained equal amounts of slow and fast fibers (similar to55%:45%); clearly distinguishing between two compartments. Atrophy of muscle fibers and fiber type grouping were also present in both normal and affected subjects; providing no clear confirmation of the clinical findings of vocal fold immobilization. Further study of the PCA muscle from patients with unilaterally immobilized vocal folds is needed.