Morphologic three-dimensional scanning of fallopian tubes to assist ovarian cancer diagnosis
Morphologic three-dimensional scanning of fallopian tubes to assist ovarian cancer diagnosis
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DOI：
10.1117/1.jbo.22.7.076012
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发表时间：
2017-07-01
影响因子：
3.5
通讯作者：
Godbout, Nicolas
中科院分区：
文献类型：
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作者：
Madore, Wendy-Julie;De Montigny, Etienne;Godbout, Nicolas
大多数高级别浆液性卵巢癌现在被认为起源于输卵管。因此，目前的做法包括对切除的输卵管进行病理检查。使用目前的临床方法检测输卵管肿瘤仍然很困难，但对于实现准确的分期和诊断至关重要。在这里，我们提出了一种术中成像系统，用于检测人类输卵管病变。该系统基于光学相干断层扫描（OCT）来获取上皮下组织结构。为了证明OCT可以识别病变，我们分析了来自5个不同卵巢病变和健康输卵管的180个OCT体积，并将其与标准病理检查进行比较。我们证明，定性特征可以匹配病理条件。然后，我们通过建立专用的内窥镜单纤维OCT探针来进入5例接受预防性手术的患者新鲜切除标本的粘膜层，确定了完整人输卵管腔内成像的可行性。探针插入管腔，在不损伤粘膜的情况下获得了整个输卵管的图像，提供了第一个完整的人类输卵管的OCT图像。(C) 2017年中国光学仪器工程师学会（SPIE）
The majority of high-grade serous ovarian cancers is now believed to originate in the fallopian tubes. Therefore, current practices include the pathological examination of excised fallopian tubes. Detection of tumors in the fallopian tubes using current clinical approaches remains difficult but is of critical importance to achieve accurate staging and diagnosis. Here, we present an intraoperative imaging system for the detection of human fallopian tube lesions. The system is based on optical coherence tomography (OCT) to access subepithelial tissue architecture. To demonstrate that OCT could identify lesions, we analyzed 180 OCT volumes taken from five different ovarian lesions and from healthy fallopian tubes, and compared them to standard pathological review. We demonstrated that qualitative features could be matched to pathological conditions. We then determined the feasibility of intraluminal imaging of intact human fallopian tubes by building a dedicated endoscopic single-fiber OCT probe to access the mucosal layer inside freshly excised specimens from five patients undergoing prophylactic surgeries. The probe insertion into the lumen acquired images over the entire length of the tubes without damaging the mucosa, providing the first OCT images of intact human fallopian tubes. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)