Tbe complete nudeotide sequences of the cloned hepatitis B vims DNA; subtype adr and adw
Tbe complete nudeotide sequences of the cloned hepatitis B vims DNA; subtype adr and adw
复制标题
T是克隆的乙型肝炎病毒DNA的完整核苷酸序列；
DOI：
--
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
K. Nishioka
中科院分区：
文献类型：
--
作者：
Y. Ono;H. Onda;R. Sasada;K. Igarashi;Y. Sugino;K. Nishioka
测定了大肠杆菌中克隆的乙型肝炎病毒（HBV） DNA的adr和adw两种不同亚型的全核苷酸序列。adr克隆的病毒基因组序列长3188个核苷酸，adw克隆的病毒基因组序列长3200个核苷酸。adr和adw克隆与报道的克隆的ayw HBV DNA（3182个核苷酸长）分别有11.2%和10.0%的核苷酸差异。观察到具有相同亚型的克隆中HBV基因组的异质性。
The complete nucleotide sequences of two different subtypes (adr and adw) of hepatitis B virus (HBV) DNA cloned in E. coli were determined. The sequence of the viral genome of the adr clone was 3188 nucleotides long, and that of the adw clone was 3200 nucleotides long. The adr and adw clones differed from the reported cloned ayw HBV DNA (3182 nucleotides long) in 11.2% and 10.0% of nucleotides, respectively. Heterogeneity of the HBV genome in the clones with the same subtype was observed.