Quaternary Ammonium Salts (QAS) Modified Polysiloxane Biocide Supported on Silica Materials
Quaternary Ammonium Salts (QAS) Modified Polysiloxane Biocide Supported on Silica Materials
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DOI：
10.1007/s10904-007-9153-0
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发表时间：
2007-07
影响因子：
4
通讯作者：
K. Rozga-Wijas;U. Mizerska;W. Fortuniak;J. Chojnowski;R. Hałasa;W. Werel
中科院分区：
文献类型：
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作者：
K. Rozga-Wijas;U. Mizerska;W. Fortuniak;J. Chojnowski;R. Hałasa;W. Werel
得到了三种乙烯基改性的二氧化硅颗粒：(I)四甲氧基硅烷(TMOS)和1，1，1，7−tetramethoxy-3，5，7-trimethyl-3，5，7-trivinyltetrasiloxane，的混合物在十六烷基三甲基溴化铵(十六烷基三甲基溴化铵)存在下水解缩聚形成的干凝胶；(Ii)由相同的前驱体在十六烷基三甲基溴化铵(CTAB)存在下得到的介孔二氧化硅；(Iii)商用的经乙烯基三乙氧基硅烷处理的硅胶60A。这些二氧化硅材料上的乙烯基团通过与HMe2SiCl的硅氢化反应转化为氯化硅烷。这些基团被用来接枝由BuLi引发的2，4，6-tri(3-chloropropyl)-2，4，6-trimethylcyclotrisiloxane阴离子开环聚合合成的活性聚硅氧烷。接枝聚合物上的氯丙基被用来季节化N，N-二甲基正辛胺。制备了接枝了季铵盐基的聚硅氧烷(QAS)的二氧化硅粒子。以正硅酸乙酯(TEOS)和3-氯丙基三乙氧基硅烷为原料，通过N，N-二甲基正辛胺作用于溶胶-凝胶法制备了表面直接附着有QAS基团的二氧化硅材料。在水悬浮液中对5株革兰氏阳性菌和革兰氏阴性菌进行了杀菌性能测试。一些二氧化硅-聚硅氧烷杂化材料对革兰氏阳性菌具有良好的抗菌性能，但不如水溶液中未捆绑的QAS取代的聚硅氧烷。直接键合到二氧化硅材料表面的QAS基团是不活跃的。
Three types of silica particles modified with vinyl groups were obtained: (i) xerogel formed by hydrolytic polycondensation of the mixture of tetramethoxysilane (TMOS) and 1,1,1,7−tetramethoxy-3,5,7-trimethyl-3,5,7-trivinyltetrasiloxane, (ii) mesoporous silica obtained from the same precursors in the presence of the cetyltrimethylammonium bromide (CTAB), and (iii) commercial Fluka silica gel 60A with a vinyltriethoxysilane-treated surface. Vinyl groups on these silica materials were transformed into silyl chloride by hydrosilylation with HMe2SiCl. These groups were used to graft living polysiloxane that was synthesized by anionic ring-opening polymerization of 2,4,6-tri(3-chloropropyl)-2,4,6-trimethylcyclotrisiloxane and initiated by BuLi. Chloropropyl groups on the grafted polymer were used to quaternizeN,N-dimethyl-n-octylamine. Silica particles with grafted polysiloxane having quaternary ammonium salt (QAS) groups pendant to polymer chains were obtained. Silica material with QAS groups directly attached to the surface were generated by the action ofN,N-dimethyl-n-octylamine on particles obtained by the sol–gel process involving tetraethoxysilane (TEOS) with 3-chloropropyltriethoxysilane. The bacteriocidal properties of all these materials were tested in water suspension against five representative strains for Gram-positive and Gram-negative bacteria. Some of the silica–polysiloxane hybrid materials have good antibacterial properties against Gram-positive strains, but not as good as the non-tethered QAS-substituted polysiloxane in water solution. The QAS groups that are directly bonded to the silica material surface are inactive.