Hepatobiliary complications of hematopoietic cell transplantation, 40 years on.

Hepatobiliary complications of hematopoietic cell transplantation, 40 years on.
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DOI:
10.1002/hep.23533
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发表时间:
2010-04
期刊:
影响因子:
13.5
通讯作者:
McDonald, George B.
McDonald, George B.
中科院分区:
医学1区
文献类型:
--
作者:
McDonald, George B.

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人类造血细胞移植(HCT)现在是许多血液恶性肿瘤和遗传性疾病患者的标准程序。从实验到标准程序的道路是困难的,因为早期的死亡率非常高,与移植相关的问题的生物学非常复杂,结果的改善必须等待更深入的科学知识。肝脏并发症已经变得不那么频繁,因为我们现在知道如何预防和治疗大多数严重的肝胆问题。1,2在在线支持性信息中,我提供了三个组织学结果的彩色板,移植适应症和HCT如何进行的简要讨论(支持性附录1),常用术语词汇表(支持性附录2),缩略语列表(支持性附录3)和主题导向的阅读列表(支持性附录4)。
Human hematopoietic cell transplantation (HCT) is now a standard procedure for many patients with hematologic malignancy and genetic disorders. The path from experimental to standard procedure has been difficult, as mortality in the early days was very high and the biology of transplant-related problems was so complex that improvement in outcomes had to wait for deeper scientific knowledge. Liver complications have become far less frequent because we now understand how to prevent and treat most of the serious hepatobiliary problems. 1, 2 In the online Supporting Information, I have provided three color plates of histologic findings, a brief discussion of indications for transplant and how HCT is carried out (Supporting Appendix 1), a glossary of common terms (Supporting Appendix 2), a list of abbreviations (Supporting Appendix 3), and a topicoriented reading list (Supporting Appendix 4).
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