HLA and T cell receptor polymorphisms in pauciarticular-onset juvenile rheumatoid arthritis.
HLA and T cell receptor polymorphisms in pauciarticular-onset juvenile rheumatoid arthritis.
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少关节型幼年类风湿关节炎中的 HLA 和 T 细胞受体多态性。
DOI：
10.1002/art.1780341009
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发表时间：
1991
影响因子：
--
通讯作者：
Concannon,P
中科院分区：
文献类型：
--
作者：
Nepom,BS;Malhotra,U;Schwarz,DA;Nettles,JW;Schaller,JG;Concannon,P
少关节型幼年类风湿性关节炎的免疫遗传学基础尚不清楚。因此，我们分析了临床明确的患者组中存在的 HLA 和 T 细胞受体基因。我们发现 DR8 单倍型贡献了大部分 HLA 相关风险，尽管其他位点的等位基因独立贡献。相比之下，在该人群中并未发现候选疾病相关 T 细胞受体多态性。讨论了这些发现的机制意义。
The immunogenetic basis of pauciarticular‐onset juvenile rheumatoid arthritis is unclear. We therefore analyzed the HLA and T cell receptor genes present in a clinically well‐defined group of patients. We found that the DR8 haplotype contributes most of the HLA‐associated risk, although alleles at other loci contribute independently. A candidate disease‐associated T cell receptor polymorphism, in contrast, was not identified in this population. Mechanistic implications of these findings are discussed.