Diffusion tensor imaging biomarkers for traumatic axonal injury: analysis of three analytic methods.
Diffusion tensor imaging biomarkers for traumatic axonal injury: analysis of three analytic methods.
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DOI：
10.1017/s1355617710001189
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发表时间：
2011-01
影响因子：
2.6
通讯作者：
Diaz-Arrastia, Ramon
中科院分区：
文献类型：
--
作者：
de la Plata, Carlos D. Marquez;Yang, Fanpei Gloria;Wang, Jun Yi;Krishnan, Kamini;Bakhadirov, Khamid;Paliotta, Christopher;Aslan, Sina;Devous, Michael D., Sr.;Moore, Carol;Harper, Caryn;McColl, Roderick;Cullum, C. Munro;Diaz-Arrastia, Ramon
创伤性轴突损伤（TAI）是创伤性脑损伤的常见机制，使用传统的神经影像学方法不易识别。弥散张量成像 (DTI) 等新型成像方式可以检测包括 TAI 在内的各种临床人群中白质 (WM) 的微观结构受损情况。 DTI 导出的数据可以使用全局方法（即 WM 直方图或基于体素的方法）或区域方法（即纤维束成像）进行分析。虽然这些方法中的每一种都产生了定性可比较的结果，但尚不清楚哪种方法在临床研究和最终临床实践中最有用。本研究比较了三种分析 DTI 衍生数据的方法，以检测 WM 损伤及其与临床结果的关联。使用 3T 磁铁对 30 名 TAI 患者和 19 名人口统计学相似的正常对照进行扫描。患者在受伤后大约八个月接受扫描，并在当时接受结果评估。 FA 和 MD 的直方图分析显示患者和对照之间的整体 WM 完整性差异。基于体素和纤维束成像分析显示，TAI 涉及的中心轴结构内 FA 显着降低。所有三种技术都与功能和认知结果相关。 DTI 对微观结构完整性的测量似乎很可靠，因为所研究的三种分析技术显示出足够的实用性来检测 WM 损伤。
Traumatic axonal injury (TAI) is a common mechanism of traumatic brain injury not readily identified using conventional neuroimaging modalities. Novel imaging modalities such as diffusion tensor imaging (DTI) can detect microstructural compromise in white matter (WM) in various clinical populations including TAI. DTI-derived data can be analyzed using global methods (i.e., WM histogram or voxel based approaches) or a regional approach (i.e., tractography). While each of these methods produce qualitatively comparable results, it is not clear which is most useful in clinical research and ultimately in clinical practice. This study compared three methods of analyzing DTI-derived data with regard to detection of WM injury and their association with clinical outcomes. Thirty patients with TAI and 19 demographically similar normal controls were scanned using a 3T magnet. Patients were scanned approximately eight months post-injury, and underwent an outcomes assessment at that time. Histogram analysis of FA and MD showed global WM integrity differences between patients and controls. Voxel-based and tractography analyses showed significant decreases in FA within centroaxial structures involved in TAI. All three techniques were associated with functional and cognitive outcomes. DTI measures of microstructural integrity appear robust, as the three analysis techniques studied showed adequate utility for detecting WM injury.