Solid-phase synthesis of imprinted nanoparticles grafted on gold substrates for voltammetric sensing of 4-ethylphenol
Solid-phase synthesis of imprinted nanoparticles grafted on gold substrates for voltammetric sensing of 4-ethylphenol
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DOI：
10.1016/j.snb.2016.02.018
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发表时间：
2016-11-29
影响因子：
8.4
通讯作者：
Barrioa, R. J.
中科院分区：
文献类型：
--
作者：
Garcia-Mutio, D.;Gomez-Caballero, A.;Barrioa, R. J.
基于分子印迹高亲和力纳米颗粒的伏安传感器已开发出来，用于直接、选择性和无标记检测 4-乙基苯酚 (4EP)。通过最近开发的分子印迹纳米粒子固相合成方法成功地印迹了功能较差的模板4EP。这些纳米颗粒被接枝到金电极的表面，可以选择性且灵敏地检测 4EP。通过循环伏安法和电化学阻抗谱对电极修饰过程的每个步骤进行了表征。对所开发传感器的电化学响应进行了评估，获得了 0.24 至 5 mg L-1 之间的线性范围，以及良好的重复性（RSD < 10%）。事实证明，该传感器能够比结构类似物特异性识别目标化合物，包括属于同一代谢途径的化合物，例如香豆酸乙酯、香豆酸和4-乙烯基苯酚，或其他酚类化合物，例如4-乙基愈创木酚或扑热息痛。 (C) 2016 Elsevier B.V. 保留所有权利。
A voltammetric sensor based on molecularly imprinted high affinity nanoparticles has been developed for the direct, selective, and label-free detection of 4-ethylphenol (4EP). The poorly functionalised template 4EP, was successfully imprinted by the recently developed method of solid-phase synthesis of molecularly imprinted nanoparticles. These nanoparticles were grafted to the surface of gold electrodes allowing for selective and sensitive detection of 4EP. Each step of the electrode modification process was characterised by cyclic voltammetry and electrochemical impedance spectroscopy. The electrochemical response of the developed sensor was evaluated and a linear range between 0.24 and 5 mg L-1 was obtained, together with good repeatability (RSD < 10%). The sensor was proven to recognise specifically the target compound over structural analogues, including compounds that belong to the same metabolic pathway such as coumaric acid ethyl ester, coumaric acid and 4-vinylphenol, or other phenolic compounds such as 4-ethylguaiacol or paracetamol. (C) 2016 Elsevier B.V. All rights reserved.