CCR5 receptor -: Biologic and genetic implications in age-related diseases
CCR5 receptor -: Biologic and genetic implications in age-related diseases
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DOI：
10.1196/annals.1395.014
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Candore, Giuseppina
中科院分区：
文献类型：
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作者：
Balistreri, Carmela Rita;Caruso, Calogero;Candore, Giuseppina
CC趋化因子受体5（CCR 5）是CC趋化因子受体家族的成员。CCR 5具有七跨膜G蛋白偶联受体（GPCR）的特征结构，其调节记忆/效应Thl细胞、巨噬细胞、NK细胞和未成熟树突细胞的运输和效应子功能。CCR 5及其配体是病毒致病过程中的重要分子。CCR 5代表巨噬细胞（M）和双重（T细胞和M）嗜性免疫缺陷病毒的共受体。最近的证据也证明了CCR 5在各种人类疾病中的作用，从感染性和炎症性疾病到癌症。在这篇文章中，我们描述了CCR 5参与两种年龄相关疾病，动脉粥样硬化和阿尔茨海默病，提示趋化因子系统在这些疾病的病理生理中可能发挥作用。最后，我们回顾了CCR 5 Delta 32缺失与心血管疾病和阿尔茨海默病之间可能存在的相关性。
The CC chemokine receptor 5 (CCR5) is a member of CC-chemokine receptor family. CCR5 has the characteristic structure of a seven transmembrane G protein-coupled receptor (GPCR), which regulates trafficking and effector functions of memory/effector Thl cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands are important molecules in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Recent evidence has also demonstrated the role of CCR5 in a variety of human diseases, ranging from infectious and inflammatory diseases to cancer. In this article, we describe the involvement of CCR5 in two age-related diseases, atherosclerosis and Alzheimer's disease, suggesting a possible role of chemokine system on these diseases' pathophysiology. Finally, we review the data on the probable association between CCR5 Delta 32 deletion and cardiovascular diseases and Alzheimer's disease.