Highly sensitive and selective dopamine biosensor based on 3,4,9,10-perylene tetracarboxylic acid functionalized graphene sheets/multi-wall carbon nanotubes/ionic liquid composite film modified electrode.
Highly sensitive and selective dopamine biosensor based on 3,4,9,10-perylene tetracarboxylic acid functionalized graphene sheets/multi-wall carbon nanotubes/ionic liquid composite film modified electrode.
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DOI：
10.1016/j.bios.2012.08.025
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发表时间：
2013-03
影响因子：
12.6
通讯作者：
Xiuli Niu;Wu Yang;Hao Guo;Jie Ren;Jinzhang Gao
中科院分区：
文献类型：
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作者：
Xiuli Niu;Wu Yang;Hao Guo;Jie Ren;Jinzhang Gao
基于3，4，9，10-二萘嵌苯四甲酸功能化石墨烯片、多壁碳纳米管和离子液体修饰玻碳电极，制备了一种灵敏、选择性测定多巴胺（DA）的电化学传感器。该修饰电极对DA的氧化具有良好的电催化活性，并提出了DA氧化的可能机理。在500μM抗坏血酸和330μM尿酸存在下，用微分脉冲伏安法测定DA，DA的浓度在0.03μM ~ 3.82mM范围内与峰电流呈良好的线性关系，检出限为1.2×10− 9 M（S/N=3）。该方法用于真实的样品中DA的测定，结果令人满意。结果表明，该修饰电极具有良好的催化活性、灵敏度、重现性和长期稳定性。
A sensitive and selective electrochemical sensor for determination of dopamine (DA) was fabricated based on 3,4,9,10-perylene tetracarboxylic acid functionalized graphene sheets, multi-wall carbon nanotubes and ionic liquid modified glass carbon electrode and the properties of modified electrode were characterized by scanning electron microscopy, transmission electron microscope and electrochemical impedance spectroscopy. The modified electrode showed excellent electrocatalytic activity toward the oxidation of DA. Meanwhile, a possible reaction mechanism related to the oxidation of DA was proposed. The differential pulse voltammetry was used for the determination of DA in the presence of 500μM ascorbic acid and 330μM uric acid under the optimum conditions and a good linear relationship between peak current and the concentration of DA was obtained in the concentration range from 0.03μM to 3.82mM with a detection limit of 1.2×10−9M (S/N=3). Moreover, the proposed method was successfully applied to determine DA in real sample and satisfactory results were obtained. The results showed that the modified electrode exhibits an excellent catalytic activity, good sensitivity, reproducibility and long-term stability.