Cyclotron Phase-Coherent Ion Spatial Dispersion in a Non-Quadratic Trapping Potential is Responsible for FT-ICR MS at the Cyclotron Frequency
Cyclotron Phase-Coherent Ion Spatial Dispersion in a Non-Quadratic Trapping Potential is Responsible for FT-ICR MS at the Cyclotron Frequency
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非二次捕获势中的回旋加速器相位相干离子空间色散是回旋加速器频率下 FT-ICR MS 的原因
DOI：
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发表时间：
2017
影响因子：
3.2
通讯作者：
Y. O. Tsybin
中科院分区：
文献类型：
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作者：
K. Nagornov;Anton N. Kozhinov;Y. O. Tsybin
摘要使用窄孔径检测电极 (NADEL) ICR 单元，通过实验证明了在回旋加速器频率而不是降低的回旋加速器频率下的傅里叶变换离子回旋共振质谱 (FT-ICR MS)。在这里，基于 SIMION 模拟的结果，我们提供了 FT-ICR MS 中回旋加速器频率范围生成的初步机制见解。回旋加速器频率范围的原因被发现是一种新型的离子集体运动，其初始特性具有一定的分散性，例如预激离子速度，在 NADEL ICR 单元中实现的高度非二次捕获势中。在离子检测期间，相同 m/z 的离子对于回旋加速器离子运动同相移动，但对于磁控管（漂移）离子运动异相移动，从而破坏了包含减少的回旋加速器频率分量的基波和高次谐波的信号。在最初的磁控管运动周期之后，离子云分布成一种新型结构——离子板、椭圆柱或星状结构。这些结构在与磁场正交的平面上以拉莫尔（半回旋加速器）频率旋转，在每个窄孔径检测电极上感应出真实回旋加速器频率的信号。为了消除偶极离子检测时回旋加速器频率峰值的降低，形成了许多组织成星状结构的板或椭圆柱。在具有四极离子检测的 NADEL ICR 单元中，单个板或椭圆柱足以最小化降低的回旋加速器频率分量的强度，特别是二次谐波。
图形摘要ᅟ
AbstractFourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) at the cyclotron frequency instead of the reduced cyclotron frequency has been experimentally demonstrated using narrow aperture detection electrode (NADEL) ICR cells. Here, based on the results of SIMION simulations, we provide the initial mechanistic insights into the cyclotron frequency regime generation in FT-ICR MS. The reason for cyclotron frequency regime is found to be a new type of a collective motion of ions with a certain dispersion in the initial characteristics, such as pre-excitation ion velocities, in a highly non-quadratic trapping potential as realized in NADEL ICR cells. During ion detection, ions of the same m/z move in phase for cyclotron ion motion but out of phase for magnetron (drift) ion motion destroying signals at the fundamental and high order harmonics that comprise reduced cyclotron frequency components. After an initial magnetron motion period, ion clouds distribute into a novel type of structures – ion slabs, elliptical cylinders, or star-like structures. These structures rotate at the Larmor (half-cyclotron) frequency on a plane orthogonal to the magnetic field, inducing signals at the true cyclotron frequency on each of the narrow aperture detection electrodes. To eliminate the reduced cyclotron frequency peak upon dipolar ion detection, a number of slabs or elliptical cylinders organizing a star-like configuration are formed. In a NADEL ICR cell with quadrupolar ion detection, a single slab or an elliptical cylinder is sufficient to minimize the intensity of the reduced cyclotron frequency components, particularly the second harmonic.
Graphical Abstractᅟ
影响因子：
7.4
作者：
Zubarev, RA;Horn, DM;McLafferty, FW
通讯作者：
McLafferty, FW
具有四个窄孔径检测电极的离子回旋共振池中四极离子检测的多粒子模拟
影响因子：
3.2
作者：
Driver, Joshua A.;Nagornov, Konstantin O.;Kozhinov, Anton N.;Tsybin, Yury O.;Kharchenko, Andriy;Amster, I. Jonathan
通讯作者：
Amster, I. Jonathan